The binding force with which a ligand binds to a receptor molecule often has profound downstream effects on a biological system. Such interactions are important in cell signaling and pharmaceutical research, among other areas. Force-distance measurements enable researchers to study attractive and repulsive forces on a probe as it approaches and retracts from a sample surface. Additional data can be obtained by attaching molecules of interest to the probe tip.
Force-distance techniques are commonly applied to investigating fundamental force interactions, nano-scale adhesive and elastic response, binding forces, colloidal studies, and chemical sensing. Force-distance is just one technique in Bruker’s comprehensive nanomechanics solutions, along with PeakForce QNM® and quantitative Force Volume mapping.