Atomic Force Microscopy Webinars

AFM Applications in Biomedical Research and Applications

Hear from our guest speakers about their work, using AFM for biomechanics, and how AFM technology impacts popular fields of biomedical research


The development of advanced targeted diagnostics and therapies often relies on single-cell- and single-molecule-level nanomechanical property investigation.

This webinar explores how AFM technology contributes to biomedical research by enabling the characterization of the nanomechanical properties of molecules, cells, and tissues as well as the visualization of structural changes taking place at the molecular level.

 

Find out more about the technology in this webinar or our other solutions for biomedical research:

Recorded on December 15, 2021

Program Overview

Explore the advanced characterization techniques  enabling researchers to gain a better understanding of the biophysical and mechanical properties of biological materials

These include:

  • Examination of the morphological and mechanical properties;
  • Collection of adhesion measurements, including the work and force necessary for cell-cell detachment; and
  • Using AFM technology as a tool for clinical prognosis.

WATCH ON DEMAND | 20 MINUTES

The Impact of Drug Resistance on Ovarian Cancer Spheroids - Insights from the Biomechanical Phenotype

Lydia Powell, Ph.D.
CEAT, Swansea University Medical School

The presentation details the development of 3D spheroid specific image and force analysis in the research programme of the Cluster for Epigenomic and Antibody Drug Conjugate Therapeutics (CEAT) at Swansea University’s Medical School, Wales.

WATCH ON DEMAND | 30 MINUTES

AFM-based Assessment of Cardiovascular Risk

Nuno C. Santos, Ph.D.
Institute of Molecular Medicine
Faculty of Medicine, University of Lisbon


This presentation explores how AFM can be used to better understand how fibrinogen-erythrocyte binding influences erythrocyte aggregation and how it constitutes a cardiovascular risk factor in different cardiovascular diseases.

Speakers

With introduction, Q&A, and conclusion led by Carmen Pettersson, Marcom Manager, Bruker EMEA.

Lydia Powell, Ph.D., Swansea University Medical School, Wales, UK

Dr. Lydia Powell is a senior post-doctoral researcher, operating at the interface between life sciences and engineering. Having originally graduated in chemical engineering, Lydia then developed expertise in advanced characterization techniques to understand the biophysical and mechanical properties of complex 3D multicellular aggregates. Using multi-disciplinary approaches, Lydia’s research has provided pivotal understanding in this area that has been translated into the design and delivery of new therapies for cystic fibrosis and chronic wound bacterial biofilm-related infections, in collaboration with industry (AlgiPharma AS and Qbiotics).

In 2018, Lydia moved to Swansea University Medical School to accelerate her translational post-doctoral research as part of the CEAT project. Lydia is currently developing advanced bio-AFM-based analysis approaches to complement epigenetic drug and antibody therapeutic platform development, alongside a host of national and multinational industry partners.

Her research interests are at the interface of cellular biophysics, mechanobiology, computer vision, and machine learning, with the strong aim of furthering the understanding of the biological processes involved in physiology and disease.

The research carried out in her lab focuses on the cell's cytoskeleton, and in particular, the characterization of its organization and mechanical properties. To do so, her lab uses a broad cellular biophysics toolbox, which includes Atomic Force Microscopy, Traction Force Microscopy, high-throughput imaging, advanced image quantification pipelines and machine learning methods.

Nuno C. Santos, Ph.D., Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Portugal

Dr. Nuno C. Santos, born in Lisbon, Portugal, in 1972, graduated in Biochemistry from the Faculty of Science, University of Lisbon, in 1995, and received his PhD in Theoretical and Experimental Biochemistry in 1999 from the same University, although all the experimental work was conducted at Instituto Superior Técnico (Technical University of Lisbon) and University of California (Santa Barbara). Currently, he is Associate Professor with Habilitation of the Faculty of Medicine, University of Lisbon, and Head of the Biomembranes & Nanomedicine Unit at the Institute of Molecular Medicine (iMM).

Among other distinctions, his research work was awarded with the Gulbenkian Prize for young researchers (2001), Dr. José Luis Champalimaud Prize – Basic Research (2004), Dr. José Luis Champalimaud Prize – Applied Research and Technology (2005) and the ULisboa – Caixa Geral de Depósitos Prize (2017). He is (co)author of 161 articles in peer-reviewed international journals, which have received over 7500 citations (h-index 47 and i10-index 128, publishing since 1996), presenting a Web of Knowledge impact factor sum of 818.7 (average 5.1 per article). In addition to these publications, he (co)authored 10 articles in Portuguese scientific journals, 15 book chapters (mostly published outside Portugal, in English), 3 books (editor, published by Wiley, Springer and MDPI) and 2 international patents.

Among different National and International research projects, he was the coordinator of a consortium funded by the 7th Framework Programme of the European Union (FP7) which included 10 different research groups from Europe and Brazil. He has been the President of the Portuguese Biophysical Society (SPBf) since 2015, member of the Executive Committee of the European Biophysical Societies’ Association (EBSA) since 2019, and Director of the M2B-PhD Doctoral Program in Medical Biochemistry and Biophysics (involving 5 different institutions) since 2016. He has supervised 11 completed PhDs, 8 as main supervisor and 3 as co-supervisor.

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Discover how AFM technology provides answers to critical questions in biomedicine.

Viewers can expect to:

  • Gain new insight into leading-edge AFM-based biomedical research;
  • Learn how innovation in AFM technology and techniques creates new opportunities in both laboratory and clinical settings;
  • Apply AFM capabilities and findings to real-world questions in biomedicine; and
  • Understand the role of AFM in multi-disciplinary approaches to solving them.

 

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