The timsTOF represents the next generation of ion mobility mass spectrometers

Adding the 4th dimension

Increases depth of LC-MS/MS workflows

Punti salienti



Consistently high ion mobility resolution unravels the complexity of samples and unlocks insights that remain hidden in standard mass spectrometry.
Adjustable ion mobility separation based on TIMS allows the exploration of samples in diverse and meaningful ways.
Boosts confidence and specificity of compound identification with an expanded set of orthogonal qualifiers that are measured with great accuracy.



Next generation ion mobility separation

  • Are your analyses blind to some compounds, like structural isomers?
  • Does trying to resolve overlapping fragment ion spectra give you a headache?
  • Is your mass spectrometer as flexible as you need for everyday challenges in the lab?

Ion mobility is a powerful extension to mass spectrometry that delivers information about the three dimensional structure of an ion, and increases peak capacity and confidence in compound characterization.

timsTOF was engineered by Bruker experts as an open platform to accelerate the adoption of ion mobility-mass spectrometry analysis across research applications.

The highly unique TIMS design enables unmatched duty cycle (up to 100%), significant improvement in IMS resolution (R>200), unprecedented collisional cross section (CCS) reproducibility and high sensitivity.




Flexibility to empower your ideas

With the flip of a switch, augment the peak capacity of your analytical system beyond chromatography and time-of-flight separation. No penalty in analysis time, no penalty in sensitivity.

timsTOF features adjustable ion mobility separation based on Trapped Ion Mobility Spectrometry (TIMS), so you can explore samples in various and meaningful ways. Furthermore, timsTOF uses an open data format (*.tdf) that introduces full transparency, efficiency and flexibility into your data analysis strategy.



Resolution - More control, more answers

timsTOF combines high ion mobility resolution with ultra-high resolution QTOF technology for optimal performance. imeXTM technology further boosts the functionality by making ion mobility resolution an adjustable parameter.

Investigate your sample in imeX survey mode for mobility-resolved full scans, and then extend your workflow with a detailed examination of selected compounds and precise collisional cross sections (CCS). Increase ion mobility resolution up to 200 for unique insights into your samples in imeX ultra mode.


Confidence - Expand what you know about a compound

Confident identification of compounds is based on orthogonal qualifiers that are reliably reported with high accuracy. With timsTOF, exact mass measurements (low ppm) are complemented with Bruker’s unique isotopic pattern fidelity (True Isotopic Pattern or TIPTM) and precise collisional cross section determination (<0.5% RSD).

Instrument geometry and the positioning of ion mobility separation prior to quadrupole isolation and fragmentation generate clear fragmentation spectra to further enhance certainty of identifications.



Deep characterization of molecules for diverse research applications

Analyze isomeric compounds
Ion mobility separation is a very powerful approach to separate isobaric or isomeric compounds. Especially in combination with high resolution accurate mass spectrometry, ion mobility separation greatly enhances substance identification and characterization capabilities, and provides an additional physical property of compounds, the CCS values.

High confidence forensic screening
Ion mobility combined with high resolution (HRES) mass spectrometry allows for the identification and characterization of known as well as unknown designer drug analytes and their metabolites.  

Characterize plant metabolites and secondary metabolites




„We are already using ion mobility in our lab, but with the much higher ion mobility resolution that timsTOF provides now, there is a lot of room for different applications based on this technology.“

Prof. Carlos Afonso, Professor of Chemistry, Université de Rouen-Normandie,  France


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