NMR SOFTWARE

Advanced Chemical Profiling 2.0

Bruker‘s Next-Generation Solution for Quantitative NMR Workflow Automation

From Spectra

To Answers

ACP 2
ACP 2

Highlights

Automated
End‑to‑End Workflow
Delivers fully automated NMR analysis from sample to report, ensuring consistent, expert‑level results across any lab.
Standardized Decision Making
Embeds reliable pass/fail logic into workflows, eliminating subjective interpretation and ensuring harmonized global decision making.
High Throughput, Compliant Analysis
Accelerates complex workflows with on‑the‑fly or batch processing, boosting productivity and reducing time‑to‑decision.
Precision Through High‑Performance Algorithms
Applies advanced fitting and deconvolution methods to deliver accurate, reliable quantification across even the most complex spectra.

Advanced Chemical Profiling 2.0: One software platform for quantitative NMR Workflows at any field strength

Advanced Chemical Profiling 2.0  is Bruker’s next‑generation software designed to transform quantitative NMR analysis into a fully automated, scalable, and operator‑independent workflow.

It helps laboratories harmonize analytical methods across research, development, manufacturing, and quality control. The fully automated, end‑to‑end NMR workflow increases throughput and efficiency while reducing costs through standardized, GMP‑ready, operator‑independent analysis

ACP 2.0 delivers consistent, high‑quality results by eliminating manual interpretation, enabling confident use in both expert and non‑expert environments. Its standardized pass/fail logic, shareable methods, and seamless integration with Bruker NMR systems and TopSpin™ ensure reproducible outcomes across instruments, sites, and global operations.

With intuitive setup, advanced algorithms, and broad application coverage, ACP 2.0 unlocks deep analytical insights while simplifying everyday work, supporting labs across chemical industry, food, pharmaceutical quality control and development workflows, and academic metabolomics research.

Enabling concepts like Lab-of-the-Future, it unites automation, harmonization, and usability to drive scientific excellence and operational efficiency at scale.

Software Download

 

Advanced Chemical Profiling 2.0

  • Download software and comprehensive tutorial videos
  • Install without administrator privileges
  • Familiarize yourself with the capabilities of ACP 2.0 using the out-of-the-box example datasets
  • Contact us for a free-of-charge 90-day demo license (Request demo license)

 

Discover Tutorials

You will find step-by-step video tutorials in the installation folder about:

  • Installation and Testing
  • Installation and Testing for GxP Readiness
  • Calibration Setup
  • Targeted Quantification
  • Fingerprinting
  • Extended Configuration
  • Report Customization
  • Viewer for Spectra Inspection

Features

Workflow Automation – at any Field


  • Fully Automated Workflow
    ACP 2.0 delivers a seamless, end-to-end workflow - from sample submission to final report - eliminating manual steps and ensuring consistent, operator-independent results across any skill level.
  • One Software Platform. All Bruker NMR
    Compatible with both benchtop and high-field Bruker NMR systems, the software ensures high-performance analyses at any field and effortless rollout across R&D, QC, and manufacturing sites.
  • Integrated with TopSpin, lconNMR, SpinPilot & GoScan
    ACP 2.0 seamlessly merges acquisition, processing, data analysis, and reporting, enabling hands-off operation without additional training. Operators interact only with familiar Bruker software environments.
  • Powerful Batch & On-the-Fly Processing
    Analyze multiple samples or time-course datasets in one run. Batch tools increase throughput, while on-the-fly analysis provides immediate insights after measurement.

Reporting made easy – customized, standardized, compliant

  • Instant, Compliant Reporting
    Generate clear, detailed PDF reports or export structured machine-readable files to feed LIMS systems, empowering real‑time data use and supporting regulatory GMP/GLP compliance.
  • Customizable Reporting & Calculations
    Adjust report formats and apply custom calculation rules (e.g., purity, monomer ratios, total sugar), eliminating the need for external tools and unifying all outputs in one system.
  • Standardized Pass/Fail Decisions
    Embedded decision logic automates assessments for incoming goods, in-process control, and batch-release - accelerating decision-making while ensuring full harmonization across sites.

From simple to complex – for 1H and any X-nuclei

  • Automated Identification & Quantification
    Advanced algorithms perform identification and quantification without expert interpretation, enabling novices to execute high-value analyses and ensuring cross-site comparability.
  • Powerful Tools for Complex Spectra
    Advanced region integration, smart modelling, signal fitting and baseline handling enable precise analysis even in challenging samples with overlaps or macromolecular background.
  • X·Nuclei Ready
    Automate identification and quantification for X-nuclei 1 D-NMR spectra, unlocking valuable information beyond standard proton NMR.

Harmonize – globally

  • Shareable Methods & Databases
    Methods, compounds and databases defined in ACP 2.0 can be shared across teams, authorities, or sites, enabling harmonized deployment and reducing duplication of work.

Benefits

  • Automation & Accessibility
    ACP 2.0 delivers fully automated, end-to-end NMR workflows that eliminate manual intervention, enabling consistent, high-quality analysis even in non-expert environments.
  • High Throughput & Efficiency
    ACP 2.0 accelerates analytical workflows through on-the-fly analysis or batch processing as well as streamlined data handling, significantly increasing throughput and freeing up expert time.
  • Standardization & Decision Support
    ACP 2.0 empowers standardized, data-driven decision-making by automating pass/fail assessments for critical control points in chemical production.
  • Knowledge Sharing & Harmonization
    ACP 2.0 facilitates seamless sharing of analytical methods across teams and sites, driving harmonization and collaboration in global organizations.
  • Usability & User Experience
    ACP 2.0 combines powerful analytical capabilities with an intuitive interface, enabling users to set up sophisticated NMR workflows with just a few clicks.

 

Unlocking NMR Potential: Elevating NMR Beyond Structural Elucidation

Research & Development

ACP 2.0 provides deep chemical insight for R&D teams by automating identification, quantification, and characterization workflows. It supports rapid formulation work, impurity profiling, stability studies, and method development by extracting rich information from even complex spectra. Scientists gain faster, clearer answers and can focus their time on innovation rather than routine analysis.

Process & In‑Process Control

In manufacturing environments, ACP 2.0 standardizes analytical evaluation of in‑process samples, enabling rapid, data‑driven decisions during production. Automated pass/fail logic ensures consistent evaluation of critical parameters, reduces interpretation errors, and accelerates reaction monitoring, process adjustments, and troubleshooting during scale‑up or continuous production.

Quality Control & Batch Release

For QC laboratories, ACP 2.0 guarantees harmonized, operator‑independent results across global sites. Automated quantification, structured reporting, and machine-readable data transfer strengthen compliance and deliver high confidence in purity checks, concentration assessments, and conformity evaluations of incoming goods, intermediates, and final products. This ensures reliable, repeatable decisions and shortens release timelines.

On‑Site and Decentralized Analysis

ACP 2.0 enables high‑performance analytical capabilities to move closer to the production floor. Compatible with both benchtop and high‑field NMR systems, it allows non‑experts to execute standardized methods on‑site, eliminating delays and improving uptime. Plants can benefit from immediate results, reduced back‑and‑forth with central labs, and more resilient operations.

Beyond Automation: Analytical Tool to Analyze Even Most Complex Mixture

With smart modelling, coherent fitting, baseline handling, and X‑nuclei support, ACP 2.0 readily tackles challenging samples such as polymers, fermentation media, specialty chemicals, and bioprocessing fluids – samples that are difficult to analyze manually. This unlocks insights that often require multiple orthogonal methods - enabling deeper understanding and faster troubleshooting.

Use Case Examples

Specifications

Discover some features examples in the carousel

ACP 2.0 Launch Discount

Limited‑time launch offer ready for you : 50% off ACP 2.0 for licenses purchased before August 31st, 2026*.

*Available for annual licenses only. 

Testimonials

Distributed Lab Topology Environment

Globally organized companies might request these duties from their labs

  • Method developed on R&D High-Resolution (HiRes) NMR systems​
  • Pilot manufacturing support by R&D department​
  • Volume manufacturing method development for non-expert operation (QC)​
  • QC method validation via R&D method

The Advanced Chemical Profiling Solution will support you in:

  • Direct HiRes NMR method roll-out to QC if needed
  • HiRes NMR to benchtop NMR method translation if possible​
  • Direct (HiRes/HiRes) or In-Tech (HiRes/Benchtop) method validation decreases time-to-market
  • ​Database-driven method scaling opportunity to other product lines (same instrument possible)​

 

 

Download Distributed Lab Topology eBook:

Webinars Featuring ACP 1.0

Discovery of small molecules that target RNA. NMR is the method of choice.
On Demand Session - January 29, 2025

Ensure Food Authenticity & Quality with NMR: Advanced Profiling Solutions

Nuclear Magnetic Resonance (NMR) technology offers a powerful, versatile solution for food profiling, providing significant return on investment (ROI) through its various applications. This webinar will delve into the basics of NMR, explore specific food profiler solutions, and highlight the versatility of NMR with different upgradation options. 
Discovery of small molecules that target RNA. NMR is the method of choice.
On Demand Session - March 18, 2025

Paradigm Shift in Analytical Development and Quality Control

Learn about modern and robust solutions for QC to streamline procedure life cycle management and meet the evolving regulatory framework. Discover unique GMP-compliant end-to-end solutions for qualitative and quantitative applications, from raw material testing to the control of high-value finished products.
Discovery of small molecules that target RNA. NMR is the method of choice.
On Demand Session - February 26, 2025

Explore automated workflows with the Fourier 80 benchtop NMR spectrometer

This webinar will provide an overview of Bruker’s Fourier 80 compact and cryogen-free benchtop NMR spectrometer highlighting its features, capabilities, and available accessories.
Discovery of small molecules that target RNA. NMR is the method of choice.
On Demand Session - March 19, 2025

Advanced Chemical Profiling Customer Training - Session 1

We are excited to invite you to an exclusive online training session for our Advanced Chemical Profiling (ACP) software. This session is designed to help Advanced Chemical Profiling users get the most out of the software, demonstrating its comprehensive workflow and features for fully-automated identification and quantification.
Discovery of small molecules that target RNA. NMR is the method of choice.
On Demand Session - April 29, 2025

Fully-automated Reaction Screening, Reaction Optimization And On-the-fly End-to-end NMR Data Analysis

Join us for a practical presentation of Chemspeed/ Bruker’s automation workstation with Bruker’s Fourier 80 Benchtop NMR spectrometer and Advanced Chemical Profiling software for fully automated end-to-end workflows for chemical reaction optimization
Discovery of small molecules that target RNA. NMR is the method of choice.
On Demand Session - June 25, 2025

Automated NMR Analysis for Biotech Screening Applications

Screening and identifying high-performance microorganisms are key steps in biotechnological research and development. They are pivotal for advancing scientific discovery and eventually commercializing bioprocesses at scale as it allows selecting suitable biological materials, such as enzymes, bacteria, or yeasts that perform the desired task with high selectivity and efficiency.