Discover how real-time ¹⁹F NMR monitoring with Bruker Fourier RxnLab accelerates pharmaceutical synthesis, enhances process understanding, and supports sustainable drug development.
Author(s)
Justinas Sakas, Matteo Pennestri, and Alejandro Bara-Estaún (Bruker BioSpin)
Key Benefits and Significance of the Solution
Integrating ¹⁹F NMR into pharmaceutical workflows delivers a unique combination of sensitivity, selectivity, and operational efficiency. The technology enables precise tracking of substrates, intermediates, and products, even in complex matrices, without the need for external standards. Automated data analysis with InsightMR software delivers clear kinetic profiles and mechanistic insights, supporting process intensification, scalability, and compliance with Process Analytical Technology (PAT) and Quality by Design (QbD) requirements.
3 Key Points
- Real-Time Monitoring with 19F NMR:
Utilize 19F high sensitivity to rapidly and accurately track fluorinated species, providing clear insights into reaction progress and kinetics for optimized synthesis. - Automated, User-Friendly Workflows:
Benefit from integrated hardware and software solutions that simplify reaction monitoring for both batch and flow chemistry. - Scalable Integration for PAT and QbD:
Adaptable benchtop NMR solutions support evolving research and manufacturing needs, ensuring robust process control and regulatory compliance.
Download the application note to discover how ¹⁹F NMR can transform your pharmaceutical development workflows with real-time insights, robust process control, and scalable solutions for the future of drug synthesis.