NMR & EPR Pharma Solutions

Contactless Check Weighing

One Step Contactless Check Weighing of Biologics and Potent Drugs

Established TD-NMR methods are now back in the spotlight with the rise of biotherapeutics.
High accuracy, 100% fill check of vials and syringes is now possible in a matter of seconds. The method is non invasive, preserving the sterility of the samples, and it comes in an affordable benchtop format!

Contactless Check Weighing (CCW) by the minispec is attracting more and more attention because of its matchless advantages for pharmaceutical production giving rise to optimized control of the filling lines. The benchtop minispec mq CCW utilizes TD-NMR, a magnetic resonance technology similar to MRI.
The pharmaceutical product is filled into syringes, vials or ampoules to a certain mass or volume, a quantity which has to be carefully controlled. The common method is weighing via a balance, which, for obvious reasons, is a two-step process.


CCW Calibration Curve

Calibration of the instrument is simply done by using empty vials or syringes and adding different amounts of the product of interest (see Figure). The calibration curve is highly linear in nature, since the higher the mass, the higher the signal of the minispec.

The CCW approach is unique because of:

  • One-step check weighing
  • Through-packaging measurement of the pharmaceutical compound (solid and liquid)
  • Equally well applicable to glass and plastic syringes, vials and ampoules
    Non-destructive Method, sample is available for further checks (integrity and API content)
  • Easy and straightforward calibration
  • Small footprint TD-NMR System (benchtop), maintenance free
  • 21CFRpart11 compliant frontend software
  • IQ and OQ support


Service & Life Cycle Support for Magnetic Resonance and Preclinical Imaging

Bruker’s commitment to provide customers with unparalleled help throughout the buying cycle, from initial inquiry to evaluation, installation, and the lifetime of the instrument is now characterized by the LabScape service concept.

LabScape Maintenance Agreements, On-Site On-Demand and Enhance Your Lab are designed to offer a new approach to maintenance and service for the modern laboratory