Nobel Prize

Nobel Prize Laureate Uses Bruker MALDI Technology to Enhance Research into the Complex Cycles of Organisms

25 years of MALDI

Bruker Daltonics would like to congratulate our fellow in Massachusett, Professor Michael Rosbash of Brandeis University who along with Professors Michael W. Young and Jeffrey C. Hall were awarded the 2017 Nobel Prize in Physiology or Medicine. 

Their work focused on developing fruit fly models to understand the adaptive biological circadian rhythms of organisms resulting in locating the gene responsible for systems self-regulation needed to adapt to daily environmental shifts on planet earth.

Bruker collaborated with Professor Rosbash and the lab of Professor Jeffrey Agar at Brandeis to implement a MALDI-centric approach applied to evaluating proteomic identification and quantification of neuropeptides of these fly models.  Direct desorption of material directly from the tissue of fruit fly models that had been exposed to differential light and dark conditions provided a fast method to detect, quantify, and locate neuropeptides associated with circadian regulation. Through a combination of MALDI-TOF and FTMS technologies, this workflow was shown to be effective, yet simple to implement and execute. This label-free approach described a facile and high-throughput tactic to peptide discovery that could be used in combination with established techniques such as LC-MS/MS to provide rapid screening along with localization of peptides to specific regions. More information can be found in the journal article co-authored by Brandeis and Bruker Daltonics describing this work: Salisbury et al. Molecular Brain 2013, 6:60.