Probes

Micro5

MR microscopy standard bore probe with exchangeable coils and integrated gradients for samples up to 10mm diamater.

The Micro5 probe supports Bruker‘s most powerful 3 T/m imaging gradient, delivering stunning magnetic resonance microscopy images with resolutions < 10 x 10 x 10 µm3 samples in a Bruker standard bore magnet. But the probe can also be used in wide bore and super wide bore systems. Combined with it‘s versatile exchangeable rf coils it can be adapted to perfectly match your  application, supporting sample diameters from 0.5 - 10 mm.

The Micro5 probe can also be used as a 3-axis diffusion probe or combined to increase the gradient strength in one direction. It is particularly useful to investigate anisotropic diffusion.

Features

  • Standard Bore Probe, also compatible to WB and SWB magnets
  • Gradient strength of up to 3 T/m, water cooled
  • Exchangeable rf coils
  • Micro5 rf coils (compatible to Diff50 except 10 mm coils) 2 and 4mm Solenoid
  • 5-10 mm Volume Coils (Sample transfer via SB-BST)
  • 500 µm MicroCoils
  • Double channel 5-8 mm coils and single channel 5-10 mm coils
  • Variable Temperature Control (compatible to BSVT, BCU,…)
  • Compatible to SB or WB Shim System
  • Compatible to TopShim
  • Probe body compatible to Diff50 MR Diffusion Probe

Specifications

Micro5   
Bore     SB / WB / SWB
1H frequency range 300 – 950 MHz
rf channels Two independent
Requirements MR Microscopy Accessory
Gradient     Micro5    
Directions     xyz    
Gradient strength per direction 3 T/m
ID/OD 19/40 mm
Rise Time (5-95%), 0-60A,120V < 80 µs
Cooling     Water    
Maximum current tested 60 A
Removable     Yes    
Exchangable rf coil  
Detection     single tuned, double tuned
Typical Nuclei 1H, 2H, 19F, 13C, 31P, 7Li, 19F, …
Standard sample temperature range (5 mm) -40°C.. +80°C
Sample diameter 0.5 – 10 mm

Applications

The Micro5 probe is typically used to study mineral or geologic samples, polymers, tablet dissolution kinetics, plants and seeds, bone or tissue biopsy samples, and small insects.

Fruit fly

m9

Tablet

m6

Noodles micro5

m4

Micro2.5 - CryoProbe

Bruker’s CyroProbe expertise into the field MR microscopy  is leading to new, exciting opportunities. MR Microscopy techniques for small samples with dedicated diameters 5 and 10 mm benefit from CryoProbe technology and a factor of up to 4  improvement in sensitivity on non-polar samples. 

Bruker’s CyroProbe expertise into the field MR microscopy  is leading to new, exciting opportunities. MR Microscopy techniques for small samples with dedicated diameters 5 and 10 mm benefit from CryoProbe technology and a factor of up to 4  improvement in sensitivity on non-polar samples. The superb image quality, top-of-the-line spatial resolution and/or largely reduced scan times. The MR Microscopy CryoProbe technology is based on the HR CryoProbe ensuring full compatibility to the Automatic Tuning Module (ATM) and the Cryoplatform unit.

The single or double frequency MR Microscopy CryoProbe offers variable temperature operation over the range from 0 to 80 ºC and is mounted in the Micro2.5 gradient system, which is the MR Microscopy gradient workhorse. Its gradient strength is perfect for most applications. The Micro2.5 remains in the magnet while the MicWB40 is removed from the magnet to insert the sample. It is available for WB and SWB systems. 

The MR Microscopy CryoProbe is a very dedicated and customized device. Please contact the MR Microscopy Product Management for details.

Features

  • Wide Bore Probe, also compatible to SWB magnets
  • Gradient strength of up to 1.5 T/m per axis, water cooled
  • Available for 5 and 10 mm sample diameter
  • Automatic Tuning Module (ATM)
  • Variable Temperature Control (compatible to BSVT, BCU)

Applications

The MR Microscopy CryoPorbe is the perfect solution for demanding investigations of plants, small animals, porous and inhomogeneous objects, study  fast dynamic processes or microliter spectroscopy.

Sugar transport in kangaroo paw

m1

Anatomy and Morphology of Zebra Fish

m7

Specifications

Micro2.5 CryoProbe  
Bore     SB / WB / SWB
1H frequency range 300 – 700 MHz
rf channels 1H
Requirements MR Microscopy Accessory CryoPlatform
Gradient     Micro2.5    
Directions     xyz    
Gradient strength per direction 1.5 T/m
ID/OD 40/72 mm
Rise Time (5-95%), 0-60A,120V < 100 µs
Cooling     Water    
Maximum current tested 60 A
Standard sample temperature range (5 mm) 0 – 80°C
Sample diameter 0.5 and 10 mm

Accessories

  • Automatic Tuning Module (ATM)
  • Cryoplatform-> link to cryplatform

Micro2.5 - MicWB40

The Micro2.5 / MicWB40 probe is the perfect tool for imaging of a wide range of small objects. The MicWB40 rf probe is equipped with exchangeable coils supporting sample diameters from 1 to 30 mm.

The Micro2.5 / MicWB40 probe is the perfect tool for imaging of a wide range of small objects. The MicWB40 rf probe is equipped with exchangeable coils supporting sample diameters from 1 to 30 mm. If required it can be equipped with the animal monitoring system to supervise physiological parameters of the animals (ECG, respiration, body temperature) and provide connections and masks for breathing gas anesthesia. Different type of animal beds and positioning systems are supported for the individual coil types. An optional VT set allows to control the temperature of the sample between -20°C and +60°C.

It is combined with Bruker’s Micro2.5 WB gradient system, which is the MR Microscopy gradient workhorse. Its gradient strength is perfect for most applications. The Micro2.5 remains in the magnet while the MicWB40 is removed from the magnet to insert the sample.

Features

Wide Bore Probe, also compatible to SWB magnets

Gradient strength of up to 1.5 T/m per axis, water cooled

Animal support (Triggering Unit, Anesthesia)

Exchangeable Rf coils, named ‘MicWB40’ series 

  • 2.5 mm Solenoid
  • 5-30 mm Single Tuned Coils, in part circular polarized
  • 5-25 (30) mm Double Tuned Coils

Surface Coils

Optional Variable Temperature Control (compatible to BSVT, BCU,…)

Special sample holders for glass tubes or animal beds are available. 

Applications

The MicWB40 probe is Brukers most versatile probe supporting large space (30 mm) for samples but also a high gradient strength for high resolution. It’s the Bruker MR Microscopy workhorse for all kind of samples from materials to in-vivo

Mouse Imaging

m2

Root plants

m16

Specifications

MicWB40  
Bore     SB / WB / SWB
1H frequency range 300 – 800 MHz
rf channels Two independent
Requirements MR Microscopy Accessory
Gradient     Micro2.5    
Directions     xyz    
Gradient strength per direction 1.5 T/m
ID/OD 40/72 mm
Rise Time (5-95%), 0-60A,120V < 100 µs
Cooling     Water    
Maximum current tested 60 A
Removable     Yes    
Exchangable rf coil  
Detection     single tuned, double tuned, or quadrature
Typical Nuclei 1H, 2H, 19F, 13C, 31P, 7Li, 19F, …
Standard sample temperature range (5 mm) -20 – 60°C
Sample diameter 2.5 – 30 mm

Accessories

  • 2.5 mm solenoid coil. Due to the B1 direction, the samples must be placed horizontally. 
  • 5 – 30 mm volume coil (in 5 mm steps). The sample needs to be placed manually into the rf coil. Single tuned coils up to 15 mm are linear coils, while 20-30 mm coils are circular polarized coils (needs quad combiner or two receive/transmit channels in the console). Double tuned coils (5-30 mm) are always linear. Comes with sample holder in corresponding diameter.
  • Surface coils (10, 15, 20 mm) can be tuned to a single frequency where the object needs to be placed directly on the coil and is typical used for in-vivo experiments. The animal handing is included with the coil. 
  • Animal Handling Accessory
  • Animal Monitoring Unit 

Micro2.5 - Magic Angle Spinning

Fusing Magic Angle Spinning (MAS) technology with the MR Microscopy gradient technology enables to acquire images and localized spectra of semi-solid objects due to the combination of reduced signal linewidth with a high and very linear gradient field. Rotors with a 3.2 or 4 mm diameter are offered, further on request. Besides imaging applications very slow diffusion processes can be investigated applying the strong gradient fields.

Fusing Magic Angle Spinning (MAS) technology with the MR Microscopy gradient technology enables to acquire images and localized spectra of semi-solid objects due to the combination of reduced signal linewidth with a high and very linear gradient field. Rotors with a 3.2 or 4 mm diameter are offered, further on request. Besides imaging applications very slow diffusion processes can be investigated applying the strong gradient fields.

It is combined with Bruker’s Micro2.5 WB gradient system, which is the MR Microscopy gradient workhorse. Its gradient strength is perfect for most applications. The Micro2.5 remains in the magnet while the MicWB40 is removed from the magnet to insert the sample. Utilizing the Micro2.5 gradient the maximum gradient strength of 2.5 T/m along the magic angle is reached if the x, y, z gradients are switched simultaneously. 

The MR Microscopy MAS Probe is a very dedicated and customized device. Please contact the MR Microscopy Product Management before placing an order.

Applications

The MR Microcopy Micro2.5 Magic Angle Spinning probe offers unique capabilties for imaging and diffusion experiments of semi-solid objects. 

Pulsed-Field-Gradient NMR with Magic-Angle Spinning.

http://hdl.handle.net/11858/00-001M-0000-0010-D3C3-D

Stress Dependence of 1H Diffusion in Silicon Rubber using MAS (check)

m13

Metabolite localization in living drosophila using High Resolution Magic Angle Spinning NMR

https://doi.org/10.1038/srep09872

Specifications

Micro2.5 Magic Angle Spinning  
Bore     SB / WB / SWB
1H frequency range 300 – 800 MHz
rf channels Two independent
Requirements Microscopy Accessory
Gradient     Micro2.5    
Directions     xyz    
Gradient strength per direction 1.5 T/m
ID/OD 40/72 mm
Rise Time (5-95%), 0-60A,120V < 100 µs
Cooling     Water    
Maximum current tested 60 A
Removable     Yes    

Accessories

  • MAS-3 Unit -> Link to MAS-3 / or solids page

Support

Here we should have the standard Bruker support hotlines etc

Contact Expert

MR microscopy & MR diffusion applications team: micdiff@bruker.com