Confocal Raman Microscope SENTERRA II

Confocal Raman Microscope for your Daily Work

What is the SENTERRA II?

The SENTERRA II is a confocal Raman microscope designed for straightforward, non-stop operation. Its high degree of automation allows fast and easy Raman imaging for failure analysis, quality control and scientific research.


  • Fully automated hardware
  • One-click switching of 4 built-in lasers
  • SureCalTM calibration technology
  • Fast 3D Raman imaging
  • Automate your own workflows in minutes
  • Powerful analysis and identification tools
  • 100% GMP & 21 CFR p11 compliant
  • FT-Raman for minimized fluorescence*
    *Combination with FT-IR instrumentation


  • Smooth user experience
  • Research-grade performance
  • Superb wavenumber precision
  • Self-diagnosis and automated OQ/PQ
  • Virtually maintenance-free operation

SENTERRA II Applications:

  • Pharmaceutics
  • Life Science
  • Polymers
  • Material Science
  • Forensics
  • Environment
  • Food Science

Your Raman Microscopy Companion: SENTERRA II

As we believe that reproducibility and precision are the main qualities of a good Raman microscope, there were three major design choices that led the development of Bruker’s most easy-to-use Raman microscope.

First, the SENTERRA II is fully automated including self-diagnosis and instrument tests like OQ and PQ. Change a laser by a simple mouse-click and afterwards, filter and grating are adjusted automatically.

Second, to use this automation to its full extent, we rethought calibration and created the patented SureCalTM technology. It continuously recalibrates the device and allows permanent sub-wavenumber precision.

Third, it’s about user safety - especially when beginners or students are involved. A class 1 laser housing and interlock always protects the user of any harmful laser radiation.


Your Advantage in Science and Industry: SureCal™

The real innovation for Raman microscopy is contained in this artificial term: SureCalTM. Reliable calibration, at any time and fully automated. But why is this so important?

Let us briefly recap one of the most important principles of Raman technology: External factors affect the optical and mechanical components in every Raman microscope, especially heat, vibrations, or component changes like changing filters and gratings.

Ultimately, this induces wavenumber shifts, which must be compensated by regular recalibrations. Thanks to SureCalTM, the SENTERRA II is the only Raman microscope that is always calibrated.

Don't invest your valuable time in cumbersome recalibrations - start analyzing. No matter if it is a quick material identification or the collection of a larger data set for PCA or other statistical methods.

Who it is for: Everyone.

We developed a powerful Raman microscopy platform for all kinds of applications. Its high degree of automation, compact size and efficient workflow, make the SENTERRA II an ideal tool to solve real world tasks in a quality control laboratory or to discover and pioneer in scientific research.

Want to know more? Contact us!

Raman Microscopy at new Performance Levels

Research-grade Spectroscopic Performance

The SENTERRA II provides excellent detection sensitivity and high spectral resolution without compromising confocality.

For most applications not more than the standard grating is required: It covers the full Raman spectrum in a single scan with 4 cm-1 resolution. For demanding studies such as isotope splitting or polymorphism an additional high resolution grating can be set by a mouse click.

Intuitive & Save Operation

SENTERRA II is a very comfortable and intuitive to use system both for the routine user and the expert. Hard- and software form a tightly interlinked unit.
While the operator is guided by the software through the Raman microanalytical workflow all relevant hardware adaptations are performed automatically.

Unmatched Wavenumber Precision & Accuracy

For precise results an accurate calibration of the wavelength axis is essential. Bruker's unique SureCALTM technology assures a permanent and automatic calibration of the wavelength axis at any time and without the need of any user action.

Assured Reliability

When working with the SENTERRA II you can be sure that the results will be reliable at any time. Thanks to fully automated instrument test routines the performance verification is performed without losing precious analysis time. During the actual analysis spectral precision and accuracy is assured by the permanent and automated calibration of the wavelength axis.

Raman Imaging with Convenience

SENTERRA II provides powerful confocal Raman imaging and mapping functionality that can be applied straight forward without time-consuming alignment of parameters. The combination of efficient data acquisition and a high precision mapping stage result in submicron spatial resolution and fast generation of Raman images. Even high resolution Raman images can be measured within seconds.


Overcome Fluorescence

The choice of the appropriate laser excitation line is of crucial importance for meaningful Raman spectra without disturbing background fluorescence. The combination of the SENTERRA II with FT-Raman technology adds a 4th excitation line in the near infrared at 1064nm which reduces the occurrence of unwanted fluorescence to a minimum. A straight FT-Raman microscope is available as RamanScope III.



Early on, Bruker decided address the needs of pharmaceutical companies. Therefore, SENTERRA II and OPUS and are 100% compliant with GMP and all major pharmacopoeias, 21 CFR part 11 and also follow the ALCOA+ principle. Whether locally or on a server, the SENTERRA II ensures the integrity and security of your data.

Application note R532


Polymers are indispensable and Raman microscopy can provide crucial insights into the quality control and development of plastic products. While Raman imaging yields information on material distribution, dedicated spectral libraries allow the identification of unknown compounds, fillers and additives.

AN R529

Material Sciences

Whether battery research or studies of graphene or silicon – Raman microscopy is extensively used by material scientists.
The SENTERRA II supports you with utmost precision and offers up to three excitation lasers as well as an optional coupling to FT-Raman for minimized fluorescence.

Application note R353


From the examination of potentially counterfeit art objects to varnish and fiber analyses in crime labs. Raman microscopy provides precise information about the chemical identity and origin of unknown substances. Due to the high spatial resolution down to the nanometer range, even smallest secrets are uncovered.

Forensic Analysis Brochure

Artefacts & Restoration

Historical works of art are precious and to conserve a part of human history is an exciting endeavour. The SENTERRA II is applied in the restoration of historical paintings, buildings and artwork. It offers additional tools like Raman probes and can be mounted on a gantry to cover and analyse larger paintings.

Application note R519


One of the many environmental applications is the analysis of microplastics. Again, the high spatial resolution of Raman microscopy offers significant advantages when smallest microplastic (MP) particles needs to be resolved. Automated particle identification routines enable fast and reliable analysis of MP contamination.

Microplastics Analysis and Testing
Application note R536
Application note R532