Confocal Raman Microscope SENTERRA II

Straightforward Raman Microscopy

The SENTERRA II defines a new level of spectroscopic performance and user friendliness in the class of compact Raman microscopes.

SENTERRA II is designed to deliver excellent sensitivity combined with high spectral and Raman Imaging performance. Therefore the SENTERRA II is a powerful platform for advanced research applications. Due to its high degree of automation, compact size and efficient workflow the SENTERRA II is likewise an ideal tool for solving real world tasks in the quality control laboratory.

Its unprecedented permanent stability of the wavenumber axis guarantees precise and accurate results at every time. The SENTERRA II is THE Raman microscope for both, the multi-user environment with high daily throughput and for the lab working at the forefront of scientific research.

SENTERRA II highlights:

  • Research-grade spectroscopic performance
  • Intuitive & convenient workflow due to software guidance and automated hardware
  • Unmatched wavenumber accuracy and precision by SureCALTM
  • Straightforward Raman imaging
  • Compact design with spectrometer included in the microscope
  • Full spectral range with all gratings
  • Multi laser excitation with fast switching capabilities
  • Combination with FT-Raman technology for minimized fluorescence
  • Fully automated instrument tests according to USP 1120, PhEur  2.2.48, ASTM E1840 and E2529-06
  • Full compliance with GMP/cGMP, GLP and 21 CFRp11
  • Open architecture version for the study of larger samples (e.g. in art) with high lateral resolution

Technologies used are protected by one or more of the following patents:
US 6141095, US 7102746

Contact our sales team today to learn more about the SENTERRA II!

Raman Microscopy at new Performance Levels

Research-grade Spectroscopic Performance

The SENTERRA II provides excellent detection sensitivity and high spectral resolution without compromising confocality.

For most applications not more than the standard grating is required: It covers the full Raman spectrum in a single scan with 4 cm-1 resolution. For demanding studies such as isotope splitting or polymorphism an additional high resolution grating can be set by a mouse click.

Intuitive & Save Operation

SENTERRA II is a very comfortable and intuitive to use system both for the routine user and the expert. Hard- and software form a tightly interlinked unit.
While the operator is guided by the software through the Raman microanalytical workflow all relevant hardware adaptations are performed automatically.

Unmatched Wavenumber Precision & Accuracy

For precise results an accurate calibration of the wavelength axis is essential. Bruker's unique SureCALTM technology assures a permanent and automatic calibration of the wavelength axis at any time and without the need of any user action.

Assured Reliability

When working with the SENTERRA II you can be sure that the results will be reliable at any time. Thanks to fully automated instrument test routines the performance verification is performed without losing precious analysis time. During the actual analysis spectral precision and accuracy is assured by the permanent and automated calibration of the wavelength axis.

Raman Imaging with Convenience

SENTERRA II provides powerful confocal Raman imaging and mapping functionality that can be applied straight forward without time-consuming alignment of parameters. The combination of efficient data acquisition and a high precision mapping stage result in submicron spatial resolution and fast generation of Raman images. Even high resolution Raman images can be measured within seconds.


Overcome Fluorescence

The choice of the appropriate laser excitation line is of crucial importance for meaningful Raman spectra without disturbing background fluorescence. The combination of the SENTERRA II with FT-Raman technology adds a 4th excitation line in the near infrared at 1064nm which reduces the occurrence of unwanted fluorescence to a minimum. A straight FT-Raman microscope is available as RamanScope III.

Applications of SENTERRA II

The SENTERRA II allows measuring Raman images and combines the obtained spatially resolved molecular information with high-quality microscopic images of the sample. The analysis is performed contactless and without the need of sample preparation. Chemical images of the sample surface can be achieved with a very high spatial resolution down to less than a micron. In addition depth profiling of optically transparent samples allows non-destructive sample investigation in the third dimension. Being suitable to be used for the detection, discrimination and identification of organic and inorganic materials the SENTERRA II has a wide range of applications.



  • Identification of pure polymers and blends
  • Analysis of multilayer systems
  • Characterization of polymers: crystallinity, density, conformation
  • Determination of monomer content, fillers, additives
  • Failure analysis: identification of impurities and inclusions
Sunglasses fingerprint

Coatings and Interfaces

  • Study of the composition and homogeneity


  • Differentiation of polymorphs
  • Visualization of the distribution of API and excipients in tablets
  • Failure analysis: Identification of particles & inclusions
Solar cells

Materials Science

  • Differentiation of amorphous and microcrystalline silicon
  • Characterization of novel 2D materials & carbon nanotube
Car crash


  • Identification of trace evidence from crime scenes such as fibers, particles, paint chips, etc.
  • Proof of the authenticity of works of art
  • Analysis of counterfeit documents, pharmaceuticals and money
  • Illicit drug analysis
Oil painting eye

Art and Cultural Heritage

  • Identification of materials used for art objects
  • Discrimination of genuine and fake artifacts
  • Study of preservation, degradation and aging of objects of art
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    Life Science

    • Study of the molecular composition of cells and tissue

    Contact our sales team today to learn more about the SENTERRA II!