MBT IVD-CE Certified

When every minute counts - MBT Sepsityper

For direct pathogen identification from positive blood culture bottles


Sepsis is a clinical syndrome that complicates severe infection. It is characterized by the cardinal signs of inflammation occurring in tissues that are remote from the infection.


The impact of sepsis on public healthcare

There is a high frequency of sepsis in European Intensive Care Units (ICUs) with 35% of patients having sepsis at some point of their ICU stay (Vincent JL et al. Crit Care Med 2006 34:344-353). Extrapolating from treated incidence rates in the United States, estimates go up to 19 million cases worldwide per year. The true incidence is presumably higher.

Mortality rates of sepsis are high and treatment of sepsis is very expensive. “Administration of an antimicrobial effective for isolated or suspected pathogens within the first hour of documented hypotension was associated with a survival rate of 79.9%. Each hour of delay in antimicrobial administration over the ensuing 6 hours was associated with an average decrease in survival of 7.6%.” (Kumar A et al. Crit Care Med 2006 34:1589-1596).

Whilst a broad-spectrum antibiotic is the first step in treating sepsis patients, in a high portion of cases (more than 75% of cases*) an early ID would enable a change in therapy hence lowering mortality rates, decreasing treatment costs and improving patient outcome. (*Stoneking LR, The Journal of Emergency Medicine, Vol. 44, No. 1, pp. 1–8, 2013)

Fast identification of pathogens with the MBT Sepsityper IVD-CE Kit

Gram-negative bacteria are the main cause of sepsis, followed by Gram-positives and Fungi.  Bruker‘s MBT Sepsityper kit for fast isolation of microorganisms from positive blood cultures enables fast and reliable species identification from positive blood cultures within 30 minutes.

Using this kit in your mass spectrometry identification workflow reduces the turnaround time provided by traditional positive blood culture identification workflows by up to 24 hours by eliminating the time-consuming step of culturing the microorganisms. Identification results can therefore be reported significantly more quickly to ICU consultants compared to traditional methods.

Mass spectra from blood cultures are not 1:1 comparable with spectra from other cultures. For optimum performance, Bruker has therefore developed the optional Sepsityper IVD software module for MBT Compass Software. The modified processing of measured mass spectra results in higher sensitivity than regular spectra processing without loss of specificity.

MBT Sepsityper enables faster results which physicians can act upon to manage blood stream infections, engage in the fight against resistance, and improve patient outcomes. The advantages of the MBT Sepsityper Kit have been illustrated in numerous publications.

Bruker’s Sepsityper solution is performed in conjunction with the Bruker MALDI Biotyper System; it is IVD-CE approved and is a very cost-effective alternative to molecular solutions. For further reading, click here to download the brochure.