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Molecular Biology

The FastScan Bio AFM provides a revolutionary means to new information for molecular biology.

The FastScan Bio AFM provides a revolutionary means to new information for molecular biology. Biomolecular structures can be imaged routinely with FastScan AFM in their native state using a new and simplified user-interface with immediate speed adjustments and pan & scan functions to identify the region of interest immediately and capture movies. FastScan Bio delivers lateral resolutions in the nanometer range with vertical resolutions in tenths of nanometers. In addition, the unique capability of FastScan Bio high scanning speeds provides a gateway to observing molecular motors at work. Optional capabilities provide the means to perform single molecule spectroscopy for a complete suite of high-resolution observations.

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Material Mapping

Membrane Dynamics

Biological membranes are the ideal structures to study molecular or cellular interactions outside of their complex environments.

Biological membranes are the ideal structures to study molecular or cellular interactions outside of their complex environments. FastScan Bio provides extraordinary performance with higher AFM-resolution and faster frame-rates than any other AFM making it the ideal tool for observing conformational changes in macromolecules. The combination of Bruker’s Tapping mode and exclusive PeakForce Tapping technology that enables ScanAsyst, provide the ultimate AFM imaging system for biological samples. Our data rendered with FastScan Bio demonstrates high sensitivity in force control at high scan rates without deforming lipid bilayer domains.

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Nanomanipulation

Cell Dynamics

FastScan AFM provides the ability to image live cell interactions with nanometer resolution on timescales relevant to dynamic cellular events, overcoming long-standing barriers for these observations.

FastScan Bio provides the ability to image live cell interactions with nanometer resolution on timescales relevant to dynamic cellular events, overcoming long-standing barriers for these observations. This FastScan Bio data demonstrates the first high-resolution time sequence images of the native structure of a bacterial outer membrane, obtained directly on the surface of live Escherichia coli cells. In this experiment the increased time resolution provided by FastScan Bio allowed us to observe dynamic changes in the nanoscale structure of the outer membrane in direct response to the AmP CM15, at timescales relevant to the mechanism of AmP-induced cell death (8 seconds per frame).

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Biomaterials and Biotechnology

AFM is a valuable tool for many biomaterials and biotechnology applications, including implants, cell and tissue engineering, drug delivery development, and pharmaceutical formulation.

AFM is a valuable tool for many biomaterials and biotechnology applications, including implants, cell and tissue engineering, drug delivery development, and pharmaceutical formulation. Bruker’s exclusive FastScan AFM, PeakForce Tapping and ScanAsyst provide the ideal AFM imaging capabilities for biological samples. FastScan Bio provides extraordinary performance with higher AFM-resolution and faster frame-rates than any other AFM available. In addition, the new simplified user-interface with immediate speed adjustments and pan & scan functions enable higher productivity and ease of use previously not seen with an AFM. FastScan Bio AFM is the ideal instrument for development and material characterization of biomaterials and biotechnology systems.

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