Pathology | Bruker


Quantitative Nanomechanical Diagnostics

Nanoscale mechanical property measurements in pathology are a relatively new field of research. It is becoming increasingly recognized that mechanical behavior is an essential factor in cell function and that mechanical property changes occur under certain pathological conditions. Mechanical signals communicated via mechanosensing and mechanotrasduction can regulate cell behavior and lead to structural modifications within the cell. Additionally, biochemical signals can cause cells to undergo molecular and cellular changes by altering their cytoskeleton and modifying cell interactions with the surrounding environment. Quantitative measurements of pathologically induced mechanical property changes bring new insights into the identification, evolution, and treatment of disease.

Bruker’s suite of nanomechanical testing techniques provides quantitative mechanical property characterization on the cellular level to measure the mechanical fingerprint of disease. From the stiffness of calcified tissues to the viscoelastic response and surface adhesion characteristics of soft tissues, Bruker’s Hysitron nanoindentation equipment enables the measurement of mechanical biophysical changes indicative of cellular function.

Application Notes

Standalone Test Equipment for Pathology Research

Hysitron TI 980 TriboIndenter | Bruker

TI 980 TriboIndenter

Bruker's most advanced nanomechanical and nanotribological test instrument, operating at the intersection of maximum performance, flexibility, reliability, sensitivity and speed.

Hysitron TI 950 TriboIndenter | Bruker

TI 950 TriboIndenter

Versatile nanomechanical and nanotribological test instrument, supporting a broad range of hybrid and correlative characterization techniques.

Hysitron TI Premier | Bruker

TI Premier

Dedicated nanomechanical test instruments, providing an essential toolkit for nanoscale mechanical characterization within a compact platform.

Microscope Instruments for Pathology Research

Hysitron TS 75 TriboScope | Bruker

TS 75 TriboScope

Quantitative, rigid-probe nanoindentation and nanotribological characterization on your existing AFM.

Hysitron BioSoft In-Situ Indenter | Bruker

BioSoft In-Situ Indenter

The first of its kind instrument for multiscale quantitative mechanical testing of biological materials and hydrogels.