Pharmaceuticals | Bruker


Mechanical properties of Pharmaceutical Formulations

Small differences in nanomechanical properties can cause significant changes the manufacturing performance of pharmaceuticals. In pharmaceuticals research, there is a continued push for an increased mechanistic understanding of raw material properties to have better control over drug efficacy, safety, cost and higher product reliability. For example, one active area of research is where tablets are used as a dosage form. In this case, single-crystal mechanical properties are critical and strongly influence their bulk compressibility and compactibility. Understanding the mechanical anisotropy of these materials is important to understanding manufacturing failures and optimizing materials and processes. Bruker’s suite of nanoindentation techniques provides the ability to measure directional-dependent (i.e. anisotropic) mechanical properties of small volumes of pharmaceutical compounds.

Cellular Mechanical Response to Pharmaceuticals

Many pharmaceuticals have an effect on the mechanical properties of cells and tissues. This is evident for pharmaceuticals designed to alter mechanical properties, such as those for osteoporosis, osteoarthritis, and high blood pressure. However, drugs designed for non-mechanical property altering reasons may lead to mechanical property changes due to biochemical and structure modifications of cells. Consequently, measurement of mechanical biophysical changes within the cell can infer cell state and function. Bruker has developed a comprehensive suite of nanoindentation testing techniques to accurately target individual cells/tissues containing active pharmaceutical compounds to directly correlate incipient mechanical properties.

Application Notes

Standalone Test Equipment for Pharmaceuticals

Hysitron TI 980 TriboIndenter | Bruker

TI 980 TriboIndenter

Bruker's most advanced nanomechanical and nanotribological test instrument, operating at the intersection of maximum performance, flexibility, reliability, sensitivity and speed.

Hysitron TI 950 TriboIndenter | Bruker

TI 950 TriboIndenter

Versatile nanomechanical and nanotribological test instrument, supporting a broad range of hybrid and correlative characterization techniques.

Hysitron TI Premier | Bruker

TI Premier

Dedicated nanomechanical test instruments, providing an essential toolkit for nanoscale mechanical characterization within a compact platform.

Microscope Instruments for Pharmaceuticals

Hysitron TS 75 TriboScope | Bruker

TS 75 TriboScope

Quantitative, rigid-probe nanoindentation and nanotribological characterization on your existing AFM.

Hysitron BioSoft In-Situ Indenter | Bruker

BioSoft In-Situ Indenter

The first of its kind instrument for multiscale quantitative mechanical testing of biological materials and hydrogels.

Application Notes