DIAGNOSTIC SOLUTIONS & HEALTHCARE CHALLENGES

AST / MIC / Resistance Testing

The global incidence of multi-drug resistance (MDR) among gram-negative and gram-positive pathogens has risen in recent years, with serious consequences for both hospital- and community-acquired infections.

AST / MIC / Resistance Testing

Detecting the potential resistance mechanisms and phenotypic resistance of organisms with high mortality rates such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp. and Escherichia coli is of high clinical and epidemiological importance.

Bruker offers a meaningful portfolio of MALDI-TOF based, broth microdilution and molecular assays to detect antimicrobial resistance determinants and phenotypic resistance to critically important antibiotics.

MALDI-TOF mass spectrometry has the potential to identify specific resistance markers. When using the MALDI Biotyper^® sirius IVD Systems the dedicated MBT Subtyping^® IVD Module combines the identification of important pathogens with automated subsequent detection of specific resistance markers in one automated workflow, providing a warning about a potential resistance.

With the subsequent MBT-STAR^® IVD assays, the MALDI Biotyper^® sirius IVD System combines microbial identification with phenotypic detection of carbapenemase and cephalosporinase activity.

With the negative ion mode available on Bruker’s high-end MALDI Biotyper^® sirius one Systems, analysis of lipids has become accessible for microbial research, enabling exploration of lipidomics for resistance detection. The MBT Lipid Xtract^™ Kit (RUO) allows sample preparation of the Lipid A molecule and all its modifications within less than 15 minutes and therefore delivering rapid colistin resistance detection.

The MICRONAUT and UMIC^® broth microdilution (BMD) assays provide specialty and routine antimicrobial and antifungal susceptibility testing solutions as well as convenient and flexible MIC determination of highest accuracy for single antibiotics (UMIC^®) like colistin, cefiderocol, and piperacillin-tazobactam.