AST / MIC / Resistance Testing

Bruker offers a meaningful portfolio of MALDI-TOF based, broth microdilution and molecular assays to detect antimicrobial resistance determinants and phenotypic resistance to critically important antibiotics.

MALDI-TOF mass spectrometry has the potential to identify specific resistance markers. When using the IVD MALDI Biotyper^® the dedicated MBT Subtyping^® IVD Module combines the identification of important pathogens with automated subsequent detection of specific resistance markers in one automated workflow, providing a warning about a potential resistance.

With the subsequent MBT-STAR^® IVD assays, the IVD MALDI Biotyper^® combines microbial identification with phenotypic detection of carbapenemase and cephalosporinase activity.

With the negative ion mode available on Bruker’s high-end MALDI Biotyper^® sirius Systems, analysis of lipids has become accessible for microbial research, enabling exploration of lipidomics for resistance detection. The MBT Lipid XtractTM Kit (RUO) allows sample preparation of the Lipid A molecule and all its modifications within less than 15 minutes and therefore delivering rapid colistin resistance detection.

The MICRONAUT and UMIC^® broth microdilution (BMD) assays provide specialty and routine antimicrobial and antifungal susceptibility testing solutions as well as convenient and flexible MIC determination of highest accuracy for single antibiotics (UMIC^®) like colistin, cefiderocol, and piperacillin-tazobactam.