Analytical Chemistry

Nuclear magnetic spectroscopy (NMR) fulfills many of the basic requirements of chemical analysis. It can identify and quantify matter but not directly separate it. For quantitative analysis, NMR is especially suited as it is a primary ratio method. The signal area is directly proportional to the number of spins or molecules in the sample. NMR is also non-destructive which, in most cases, allows for the complete recovery of the material. 

The use of cryogenically cooled probes, micro sample probes or a combination of the two, allows for the analysis of samples at concentration levels or amounts previously not considered feasible with NMR. Other developments in the technique such as the increased dynamic range of a modern NMR spectrometer now allow for the analysis and quantification of impurities or contaminants that are present in the ppm range. 

The true strength of NMR is the fact that the observed signal is always directly proportional to the number of the observed nuclei in the samples. All compounds in a sample have the identical response factor. There is no need to establish individual calibration curves.

Quantitative NMR or short qNMR can determine the composition of a mixture, the amount of an unknown material and the purity of compound with a basic NMR experiment. These determinations can be performed over wide ranges of absolute and relative concentrations. 
In some sense structure elucidation and verification by NMR can also be considered an analytical application.  Bruker Biospin offers dedicated software to facilitate these tasks. 

Relevant Products

Ascend 400

NMR Instruments

NMR é uma técnica analítica rica em informações e não destrutiva. Esta fornece informações detalhadas sobre a estrutura molecular, processos dinâmicos e permite a observação direta de reações químicas.

EPR Instruments

O portfólio de instrumentos de EPR de alto desempenho da Bruker oferece uma técnica analítica não destrutiva para a deteção direta de espécies paramagnéticas. Os radicais livres e iões metálicos de transição podem ser identificados e quantificados em sólidos, líquidos, gases, células e in vivo. Os conhecimentos estruturais desde a estrutura química até às interações intermoleculares são obtidos tanto a partir de técnicas de onda contínua como de EPR de pulso.


CryoProbe™ Bruker offers a whole world of applications with significantly increased sensitivity for all sizes of probes
Avance Neo Console


The AVANCE NEO consoles for NMR feature even faster control, improved dynamic range and greater flexibility and scalability than ever before.
Fourier 80

Fourier 80

Building on decades of experience creating top-quality NMR instruments, Bruker has reimagined high-performance NMR spectroscopy in a compact, cost-efficient form


The AvanceCore solution offers premium high-resolution NMR at a more affordable price, making NMR more accessible than ever before.
magnettech ESR5000

Magnettech ESR5000

The Magnettech ESR5000 is an innovative research instrument with high quality performance. It offers dedicated and tailored turn-key solutions for specific quality control, medical, and pharmaceutical R&D applications.


The microESR is a small, portable research grade instrument and is also an ideal teaching tool for undergraduate chemistry labs. The spectrometer has a mass of only 10 kg and can easily fit in a fume hood or glove box, or be transported into the field. Plus, it requires no special installation or regular maintenance.


Bruker’s TopSpin™ software package for NMR data analysis and the acquisition and processing of NMR spectra.


A powerful software tool for interactive, assisted NMR data analysis for spectra of small organic molecules.