Notch-Mutated Cancer Genomes in 3D
The recording of this live event is unavailable
Unraveling Epigenetic Changes in Cancer Cells
During this live event, guest speaker Dr. Babak Faryabi, University of Pennsylvania, discussed utilizing Oligopaint and super-resolution microscopy to investigate the role of transcription hubs in altering genome folding. Attendees learned about the power of super-resolution microscopy and chromatin tracing in understanding the three-dimensional structure of the genome in single cells.
Presenter’s Abstract
The importance of epigenetic changes in cancer pathogenesis has become increasingly clear, yet the underlying mechanisms remain obscure. Our research focuses on identifying epigenetic changes that can render cancer cells addicted to specific transcriptional regulators. I will present evidence that oncogenic subversion of transcription factors leads to disruption of chromosome topology and instruct enhancer elements to aberrantly interact and activate intact key proto-oncogenes. These aberrant epigenetic states can drive cancer cell growth and proliferation in the absence of genetic mutations and may also confer drug resistance. I will also discuss our efforts to develop single-cell molecular tools and experimental models to characterize epigenetic mechanisms of oncogenesis and attendant therapeutic opportunities.
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Guest Speaker
Babak Faryabi, Ph.D., Associate Professor of Pathology and Cancer Biology, University of Pennsylvania Perelman School of Medicine
