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Lipidomics

Profiling and Identification of lipids

The Lipidome is defined as complete lipid profile within a cell, tissue or organism, i.e. the subset of all lipids. Similar to metabolomics, in lipidomics a major aim is to discover (lipid) biomarkers characteristic for a disease, or as marker for an internal or external perturbation.

Many metabolic diseases involve lipids as regulators for complex cellular processes substantiating the increasing interest in Lipidomics research.

The complexity of the Lipidome both in dynamic range and structural diversity represents a challenge which can be readily addressed by Bruker's comprehensive product portfolio.

Bruker´s ESI-UHR-TOF instruments enable accurate mass measurements for molecular and fragment ions and NMR provides additional structure elucidation potential – altogether a powerful combination for lipid characterization. Bruker´s Ion Trap instruments, feature zero delay positive / negative polarity switching capabilities, perfectly suit the need to characterize lipid samples, as these are typically measured in both ionization polarities. Lipids, which are hard to separate by HPLC, can be characterized by the powerful combination of Thin Layer Chromatography (TLC) and MALDI-MS.