The lipidome is defined as complete lipid profile within a cell, tissue or organism, i.e. the subset of all lipids. Many metabolic diseases involve lipids as regulators for complex cellular processes substantiating the increasing interest in lipidomics research. The major aim is to discover biomarkers characteristic for a disease, or as marker for an internal or external perturbation.
In lipidomics research, the confident identification of lipids is crucial. This annotation of lipids can be demanding due to the large number of structural variations. Using Bruker’s timsTOF fleX technology, lipids can be extensively characterised giving molecular formula and chain composition using LC-PASEF and linked to the spatial distribution on tissue using the SpatialOMx® workflow.
The 4D-Lipidomics™ workflow addresses these challenges in a complete solution by providing unique benefits:
For Research Use Only. Not for use in clinical diagnostic procedures.