Brochure: Metabolomics 05-2017, (1852687)
The metabolome is the final manifestation of the
biochemical pathways that govern life. Ultimately,
temporal and spatial changes in the identity and levels
of thousands of metabolites reflect the final outcome
(phenotype) of interactions at the genomic, transcriptomic
and proteomic levels. Thus, studying the metabolome
is the cornerstone to gain deeper...
The metabolome is the final manifestation of the
biochemical pathways that govern life. Ultimately,
temporal and spatial changes in the identity and levels
of thousands of metabolites reflect the final outcome
(phenotype) of interactions at the genomic, transcriptomic
and proteomic levels. Thus, studying the metabolome
is the cornerstone to gain deeper insights.
Back
App Note: Electron Induced Dissociation for the Differentiation, 07-2017 (1851943)
Electron induced dissociation (EID) is applied for the differentiation of structural isomers
of diclofenac metabolites. EID showed superior capability over collision induced
dissociation (CID) by providing detailed structural information to locate the hydroxyl
groups on different rings.
Electron induced dissociation (EID) is applied for the differentiation of structural isomers
of diclofenac metabolites. EID showed superior capability over collision induced
dissociation (CID) by providing detailed structural information to locate the hydroxyl
groups on different rings.
Back
App Note: LCMS-119 Omics studies elucidate an increase, 01-2017 (1849580)
High performance proteomics and metabolomics studies using the impact II Q-TOF irovide insight into how rational strain design increased bio-production efficiency.
High performance proteomics and metabolomics studies using the impact II Q-TOF irovide insight into how rational strain design increased bio-production efficiency.
Back
App Note: LCMS-116 What are we eating, 07-2016 (1845963)
Determining the structure of secondary metabolites is a significant bottleneck often faced by today’s plant and food metabolomics scientists. The identification of compounds of interest is a key step for enabling the biological interpretation of observed changes in metabolite profiles. Additionally, there is a need to quickly tag those compounds which have...
Determining the structure of secondary metabolites is a significant bottleneck often faced by today’s plant and food metabolomics scientists. The identification of compounds of interest is a key step for enabling the biological interpretation of observed changes in metabolite profiles. Additionally, there is a need to quickly tag those compounds which have been characterised previously. This so-called de-replication process saves time which might otherwise be spent for the repetitive annotation of already known compounds.
Back
Poster Note: PN-33 Boosting compound identification confidence, 07-2016 (1845959)
Boosting compound identification confidence by exploiting all HRAM spectral information integrating accurate mass, true isotopic pattern, in-source fragmentation, MS/MS fragmentation, and retention time.
Confident compound identification is still a major bottleneck in metabolomics. While there are ongoing efforts to refine the definitions and levels of...
Boosting compound identification confidence by exploiting all HRAM spectral information integrating accurate mass, true isotopic pattern, in-source fragmentation, MS/MS fragmentation, and retention time.
Confident compound identification is still a major bottleneck in metabolomics. While there are ongoing efforts to refine the definitions and levels of metabolite identifications that were first proposed by the MSI initiative (1-4), it is clear that higher levels of confidence can be reached by joining accurate measurement technology, orthogonal molecular features, and sophisticated software tools.
Back
