脑缺血后小胶质细胞和星形胶质细胞中 α7 受体的表达增加。接受 PHA 568487 治疗的脑缺血大鼠中 [18F]DPA-714 的结合降低,这支持了 α7 受体在脑缺血神经炎症反应中的作用。此外,与对照组相比,PHA 568487 治疗显著降低了脑梗死体积,改善了神经系统预后。α7 nAChR 的激活对血脑屏障的渗透性无影响8。
综上所述,这些结果表明烟碱型 α7 nAChR 受体在大鼠脑缺血后的炎症反应以及白细胞聚集中发挥着重要作用。
本研究所得结果支持 α7 nAChR 受体在脑缺血后神经炎症发展中发挥作用,衷心希望这些新信息可以促进新策略和新疗法的开发,进而降低缺血性中风后的致残率,降低其他神经系统疾病的负担。
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