Fluorescence Microscopy Webinars

Automated Multiplexed 3D Super-Resolution Cell Imaging with DNA-PAINT

Find out how you can use DNA-PAINT for 3D multiplexed super-resolution imaging 

Using DNA-PAINT for impressive super-resolution imaging

Gain firsthand insights from imaging experts into how the localization-based super-resolution microscopy method DNA-PAINT works and how it can contribute to your lab. Topics discussed will include:

  • The technical background of how DNA-PAINT works
  • How to prepare your samples for DNA-PAINT imaging
  • Best practices for image acquisition and target multiplexing

Webinar Summary

Super-resolution imaging techniques have transformed biological and biomedical research by allowing researchers to observe structures well below the classical diffraction limit of light. DNA Points Accumulation for Imaging in Nanoscale Topography (DNA-PAINT) is an easy-to-implement approach to localization-based super-resolution microscopy by using small DNA probes. In DNA-PAINT, transient binding of short dye-labeled oligonucleotides (imager) to their complementary target (docking) strands creates the necessary blinking to enable stochastic super-resolution microscopy. Using the programmability and specificity of DNA molecules as imaging and labeling probes allows researchers to decouple blinking from dye photophysics. This alleviates the limitations of current super-resolution techniques and makes it compatible with virtually any single-molecule compatible dye. Furthermore, because different docking strands can be added to different targets within the same sample, there is unlimited multiplexing potential. In this webinar, we will show you how to perform multiplexed three-dimensional DNA-PAINT measurements on the Vutara VXL with an integrated fluidics unit. 

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Dr. Jürgen Schmied, CEO and Co-Founder, Photonics

Sebastian Strauss, CTO and Co-Founder, Photonics

Dr. Florian Selbach, CSO, Photonics

Dr. Lauren Gagnon

Vutara Applications Scientist, Bruker

Dr. Lauren Gagnon graduated from Emmanuel College with a degree in Chemistry before completing her PhD in Chemistry at the University of Washington. Her thesis research focused on the development of novel approaches to single molecule localization microscopy using DNA barcoded antibodies.