Complete workflow from fragment library quality check, cocktail design and automated hit identification to quantitative assessment of binding (Kd) and the 3D analysis of ligands.
Mnova Binding automatically processes protein-ligand titration 2D HSQC, tracks the peak movement and calculates the Kd’s for multiple peaks.
The 3D conformations adopted by a free ligand in solution affects binding affinity for the pharmaceutical target. Their structural analysis helps to speed up lead optimization.
Mnova StereoFitter generates 3D conformational populations using experimental NMR constraints (qNOE, chemical shift and J coupling).
Bruker’s commitment to provide customers with unparalleled help throughout the buying cycle, from initial inquiry to evaluation, installation, and the lifetime of the instrument is now characterized by the LabScape service concept.
LabScape Maintenance Agreements, On-Site On-Demand and Enhance Your Lab are designed to offer a new approach to maintenance and service for the modern laboratory