Process environments in the chemical, petrochemical and polymer industry depend on tightly controlled reaction behaviour, stable feedstock characteristics and predictable material transformations. To achieve this level of control, Process Analytical Technology (PAT) brings together real time observation of composition and structural evolution with at‑line molecular and electronic‑state analysis. Continuous insight into reaction kinetics, process variability and product‑defining attributes supports faster deviation detection, more precise process adjustments and greater alignment with Quality by Design principles. This integrated analytical framework strengthens process robustness across manufacturing lines, improves consistency in routine production and forms a reliable basis for data‑driven decisions in complex industrial workflows.
PAT for Chemicals
Chemical synthesis and blending require continuous visibility into how organic components and structures evolve under operating conditions. FT‑NIR spectroscopy tracks changes in composition online as reactions proceed; Raman spectroscopy operates online and captures structural and impurity‑related signatures in real time; FT‑IR adds functional‑group context for intermediates and endpoints when in situ monitoring is needed. Used together, FT‑NIR, FT-IR and Raman help keep reaction paths steady, maintain blend accuracy and reveal off‑trajectory chemistry before it impacts downstream steps.
In fine and bulk chemical production, NMR enables rapid characterization of intermediates and end products. Real-time monitoring supports continuous flow processes, minimizes waste, and ensures consistent quality at scale, driving efficiency and sustainability.
EPR technology monitors radicals and reaction mechanisms in specialty chemical processes. This highly sensitive, non-invasive method ensures precise control and consistent quality in complex formulations. With automation, easy calibration, and compliance with international standards, it simplifies workflows and supports QC labs in optimizing production and research environments.
Refining operations must respond to fast‑changing hydrocarbon composition during distillation, conversion and blending. FT‑NIR spectroscopy monitors changes in composition online, revealing how streams shift under dynamic conditions. Process Raman spectroscopy detects structural fingerprints even in darker or otherwise challenging matrices, flagging deviations early. FT‑IR adds functional‑group detail linked to fuel quality and reaction pathways. By combining FT‑NIR, FT‑IR and Raman, petrochemical units gain real‑time awareness that supports stable throughput and more accurate blending.
TD‑NMR allows rapid, precise hydrogen content determination for petrochemical and oil applications. Highly reproducible and requiring no sample prep, it is suitable for real‑time process control. Alignment with AOCS and ISO practices ensures compliance and reliability. With automation, robust calibration and compact operation, it simplifies workflows and supports efficient QC and production monitoring.
EPR technology is applied to analyze asphaltenes and vanadium in crude oil, providing rapid, precise quality assessment. This non‑invasive method detects paramagnetic species, ensuring reliable process control and optimization. With automation, easy calibration and compliance with international standards, it supports QC labs and refineries in maintaining consistency and improving operational efficiency.
FT‑NIR, FT‑IR and Raman spectroscopy provide real time clarity during polymerization, compounding and extrusion. FT‑NIR spectroscopy follows monomer conversion and other parameters that shape polymer quality. It also monitors how functional groups change during curing or structural modification. Raman reveals crystallinity, phase behavior and structural variations that affect processing and final material properties. Together these techniques help manufacturers maintain consistent polymer performance and respond quickly to deviations.
NMR spectroscopy offers precise analysis of polymer composition, molecular weight distribution, and crosslinking during synthesis. Inline monitoring ensures uniformity and performance, reducing defects and improving material properties for industrial applications.
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