Neuroscience

Combining imaging technologies to study the brain

Advancing preclinical neuroscience research involves a combination of imaging tools.

Neuroscience is a multidisciplinary field that encompasses a wide array of modalities to study the pathology and function of the brain. The brain holds the secret to explaining body responses in both healthy and disease states. Research of brain function is thus fundamental to understanding a range of debilitating conditions, including stroke, Alzheimer's disease, and multiple sclerosis, and developing strategies to prevent and treat them.

Brain imaging is a powerful tool for investigating brain microstructure, vasculature, and activity and how these are affected by neurological and psychiatric disorders. Advances in neuroimaging tools have allowed more and more complicated questions to be addressed. Preclinical animal imaging has proved particularly valuable, providing a high level of sensitivity and specificity and study designs not possible in clinical settings. In vivo and ex vivo imaging studies have defined the pathologic mechanisms underlying various diseases, which in turn enabled the development successful therapeutic interventions. Biomarkers and brain pathologies indicative of Alzheimer's disease identified using brain imaging are being used to develop innovative strategies to prevent clinical manifestation of this devastating condition.

Bruker offers high-field preclinical and molecular imaging systems for obtaining high-resolution visualizations of the brain, including MRI scanners specifically designed for in vivo rodent imaging, such as the Biospec 15.2 T scanner.

In addition, neuroscientists also benefit from Bruker's Positron Emission Tomography (PET) systems to obtain metabolic information. For example, PET can be used to detect changes in brain metabolic activity and receptors densities. For the best of both worlds, Bruker's portfolio features PET/MR instruments which combines MRI and PET to provide crystal clear visualization in functional and anatomical neuroimaging.