Targeting fibrotic diseases at their source: enzymes
The Nox family of enzymes (Nox1 to -5, Duox1 and -2) and mitochondrial electron transport enzymes are among the major sources of cellular reactive oxygen species (ROS), including superoxide radical anion (O2⨪), hydrogen peroxide (H2O2), and related oxidants.
Nox-related inflammatory diseases include acute respiratory disease syndrome, chronic obstructive pulmonary disease, neurodegenerative diseases (including Alzheimer disease, Parkinson disease, and ischemic stroke), and reperfusion injury occurring during transplantation. Hence, there is a need for the development of novel drugs based on new targets. Nox enzymes are a promising drug target, based on mounting evidence in humans and in experimental animal models.
Click here to see how EPR represents a most useful assay to determine Superoxide production in cells.