Preclinical Imaging’

Preclinical Imaging

How Bruker’s preclinical imaging solutions help to discover new drugs and significantly shorten time-to-market by delivering earlier and more highly predictive data.

Preclinical Imaging Life Sciences

Preclinical imaging plays a crucial role in understanding how the body works in both healthy and disease states and describing responses to physiological or environmental change. It provides important insights into disease mechanisms at organ, tissue, cell, and molecular levels.

Such knowledge informs the development of novel therapeutic strategies, which in turn improve patient outcomes and save lives. Preclinical imaging is also central to evaluating the effectiveness and safety of new treatments and describing drug distribution patterns before clinical use.

Cost-efficient and high-throughput longitudinal study of animal models can be achieved using anatomical evaluation techniques such as magnetic resonance imaging (MRI) and computed tomography (CT) alongside positron emission tomography (PET) and single-photon emission computed tomography (SPECT) for molecular visualizations.

Bruker has developed a wide portfolio of molecular imaging technologies to meet varying preclinical imaging requirements. It includes MRI and CT scanners specifically designed for in vivo rodent imaging, such as the 9.4 Tesla (T) small animal MRI scanner and the MicroCT scanner. Multimodal imaging is facilitated by the combination of technologies in a single, easy-to-use instrument, such as the Albira system that includes PET, SPECT and CT technologies and the PET/MR 3T that combines PET and MRI.

Related Applications

Oncology New

Non-invasive imaging provides key insights into tumor development, response to treatment and drug toxicity. The analytical value of individual imaging strategies can be further enhanced by combining structural and functional imaging modalities. Multimodal imaging in preclinical research using in vivo imaging allows cancer-related processes to be visualized in real time with high sensitivity and resolution. A deeper understanding of a range of tumors and improve treatment options have been obtained through the use of a variety of imaging techniques, including MRI, SPECT, PET and CT, and microCT.

Tumor Treatment | Evaluation | Tomographic Imaging | Bruker

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Zoology and Botany

The importance of non-destructive imaging in zoology and botany

Molecular Tracers and Contrast Agents

Imaging agents in preclinical research provide valuable information towards our understanding of disease models, and the findings are directly translatable to the clinic.

Cardiovascular

Bruker's preclinical imaging solutions - key players in achieving a functional assessment of the heart

Endocrinology

Bruker have developed a range of imaging systems to facilitate preclinical imaging in endocrinological research. The EVOQ Elite liquid chromatography mass spectrometer provides sustained high sensitivity detection of endocrines with high-throughput, whilst the the Bruker AVANCE range provides cutting-edge NMR performance. Additionally, the Albira preclinical micro-PET system enables full-body mice PET scans, suitable for endocrinology studies.

Virology

Lung imaging helps to understand respiratory diseases.

Mineralized Tissues

Mineralized tissues such as bone and teeth lend themselves to microCT imaging because of natural X-ray contrast

Tumor Treatment | Evaluation | Tomographic Imaging | Bruker

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