Supporting new hyperpolarization research

The pH2 Generator is an instrument designed to enrich the content of parahydrogen of normal hydrogen gas. It is intended to be used for the generation of parahydrogen in a laboratory environment. An example of laboratory use of parahydrogen is for the production of hyperpolarised substrates for NMR spectroscopy or preclinical MRI.

The pH2 Generator integrates into a single metal cabinet the following components: a valve controlled gas routing system, a conversion chamber in a vacuum enclosure, a vacuum pump, a cryo-cooler, a closed loop secondary cooling system, and an electronic unit. The instrument is connected to the mains power supply and to a supply of high purity hydrogen gas.


  • Stand-alone cryogenic device for the enrichment of the parahydrogen content of hydrogen gas
  • Essential equipment for HIP and NH-PHIP hyperpolarisation experiments
  • Specially designed for continuous flow operation, crucial for infusion
  • MRI of hyperpolarised molecules
  • Fully automatic operation
  • Simple installation; no special services such as water cooling required
  • Delivered with an electrolytic source of H2 input gas for added safety and convenience

Principle of operation

Ortho- and parahydrogen are two spin-isomers of hydrogen which at room temperature naturally occur in the ratio 3:1. Parahydrogen has a lower ground state energy than orthohydrogen and therefore, at lower temperatures the parahydrogen content increases.

The quantum-mechanical transition probability from ortho- to parahydrogen is very low unless the gas is brought into contact with a catalyst such as activated carbon. In the pH2 Generator, room temperature hydrogen gas is cooled in the cryo-cooler to below 40 K and fed through a conversion chamber with the catalyst, resulting in a parahydrogen content close to 90%.

Technical specifications:

Inlet gas H2 gas high purity 99.999 %
Inlet pressure 1 bar min, 10 bar max.
H2 flow rate 0.2 l /min max. (STP)
Conversion temperature 36 to 40 K
Cool-down time <1 hr from room temperature
Warm-up time < 20 min from conversion temperature
Outlet gas Parahydrogen fraction > 85 %
Inlet and outlet fittings G1/8 ”
Power requirements 110-230 Vac 50-60 Hz / 600 VA max.
Dimensions 68.5 cm (H) x 46.5 cm(W) x 66.5 cm (D)
Weight < 50 kg
Parahydrogen pH2 generator


Service & Life Cycle Support for Magnetic Resonance and Preclinical Imaging

Bruker’s commitment to provide customers with unparalleled help throughout the buying cycle, from initial inquiry to evaluation, installation, and the lifetime of the instrument is now characterized by the LabScape service concept.

LabScape Maintenance Agreements, On-Site On-Demand and Enhance Your Lab are designed to offer a new approach to maintenance and service for the modern laboratory

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