Biospec 117 16 USR

The BioSpec 117/16 combines the advantages of ultra-high-field with the versatility of high-field preclinical MRI instruments. With the largest range of coils to enable extreme versatility at ultra-high-field for studies on mice and rats.

It is built with a zero-helium boil-off, nitrogen-free, Ultra Shielded and Refrigerated (USR) superconducting magnet for long service intervals and reduced maintenance costs. The pulse tube cryo-cooler technology utilized in this USR magnet greatly improves cryogenic efficiency and has the additional benefit of minimizing the vibration transfer to the magnet system, which is essential for optimal imaging performance.

Application BioSpec 117 mouse primate

Mouse primate (mirocebus murinus) Alzheimer model shows significant decrease of gluCEST contrast compared to the control, reflecting a reduced glutamate concentration

Courtesy: J. Flament, C. Gary,
MIRCen, Fontenay-aux-Roses, France

  • Zero helium boil-off technology, nitrogen-free, Ultra Shielded and Refrigerated (USR) magnet technology for reduced maintenance costs and longer service intervals
  • Accurate animal positioning with the optional motorized animal handling system  
  • Full second and third order high power shim channels guarantee optimal performance for spectroscopy and imaging
  • Crisp and highly resolved images with a gradient strength of up to 760 mT/m  
  • In-house development and production of all key components (software, magnet, gradient, spectrometer, RF coils) ensures the best performance

Magnet

  • Field strength: 11.7 Tesla
  • Bore diameter: 16 cm
  • Magnet technology: Zero helium boil-off technology, nitrogen-free, Ultra Shielded and Refrigerated (USR) superconducting magnet

Gradients

  • Gradient inner diameter: 90 mm Gradient strength: 570 mT/m (760 mT/m with high power option)
  • Slew rate: 5130 T/m/s (6840 T/m/s with high power option) Actively shielded gradient system Integrated shim coils for optimal field homogeneity

Electronics

  • AVANCE NEO electronics enabling both MRI and MRS applications
  • The digital signal processing system operates at 1H resonance frequency of 500 MHz and utilizes digital filtering, digital quadrature demodulation as well as digital controls for RF amplitude stabilization for superior resolution and image quality
  • Real-time spectrometer control for optimization of acquisition parameters during scan
  • Up to 16 digital receive channels

RF Coils

  • MRI CryoProbe for exceptional increase in sensitivity
  • Volume resonators ranging from 15 mm up to 72 mm inner diameter for material research and studies on mouse
  • Complete RF coil portfolio for mice and rats available, including coils for head, brain, cardiac, spine, body, and multipurpose applications
  • Multi-channel array coils with up to 8 channels enable parallel imaging applications
  • Integrated preamplifiers guarantee optimal sensitivity over a large dynamic range
  • Hardware recognition of RF coils automatically configures all relevant parameters
  • Active RF decoupling for independent operation of transmit and receive coils


Software

  • Over 100 validated and ready to use in vivo protocols and scan programs for mice and rats
  • Fully-featured ParaVision® preclinical user user interface for streamlined workflow and most powerful analysis
  • MRI sequence portfolio of more than 1,000 sequence variations, including wireless cardiac imaging using navigator based IntraGate methods with a choice of cartesian or radial readout, as well as short echo time imaging, such as UTE and ZTE
Application BioSpec 117 mouse brain RARE

Ultra-high resolution (35 × 35 × 200) µm3 mouse brain in vivo T2-weighted RARE acquired in 21 min

Courtesy: V. Rasche, University of Ulm, Germany

Application BioSpec 117 voxel

Ultra small voxel of 2.7 µl voxel (1 × 1 × 2.7) mm³ in mouse hippocampus acquired with LASER-localization

Courtesy: M. Santin, R. Paquin et al., ICM-CENIR, Paris, France

In Vivo 3D DTI of Adult Mouse Brain

Application BioSpec 117 mricryoprobe

BioSpec® 117/16 USR with MRI CryoProbe

Using MRI CryoProbeTM at 11.7 Tesla, the anterior commissure (ac), optical track (opt), fornix-fimbria (fx-fi), stria medullaris (sm), stria terminalis (st), and fasciculus retroflexus (fr) can be seen in DTI 

Courtesy: P. van Zijl, Kennedy Krieger Institute and Johns Hopkins University, Baltimore, USA

Application BioSpec 117 PFPE

19F imaging of PFPE labeled human neural stem cells implanted into mice provides better localization and quantification than traditional 1H imaging of iron oxide nanoparticle labeled cells

Courtesy: M. Hoehn et al., MPI for Neurological Research, Cologne, Germany
Reference: Boehm-Sturm, Philipp et al. “In vivo tracking of human neural stem cells with 19F magnetic resonance imaging.” PloS one vol. 6,12 (2011): e29040. doi:10.1371/journal.pone.0029040

Application BioSpec 117 forewapsimulation

Isotropic (234) µm3, 3D zero echo time (ZTE) imaging of mouse lung at 15.2 T in 7 min.  ZTE enables lung tissue visualization with high signal and resolution and reduced motion artifacts due to radial signal acquisition

Cardiac FLASH MRI provides superior spatial and temporal resolution with visualization of all four heart chambers and aorta with 9 frames per heartbeat