Analytical Cryo-SEM EDS Mapping for Biological and Life Science Applications
Analytical electron microscopy (EM) techniques such as energy-dispersive X-ray spectroscopy (EDS) are invaluable for studying biological samples containing minerals like calcium carbonate (CaCO₃), metal ions, or other compositions beyond carbon and oxygen. However, analyzing beam-sensitive materials can be challenging due to their low signal output and long acquisition times, often leading to sample damage and loss of the measured area. The XFlash® FlatQUAD detector was utilized to overcome these challenges, enabling the study of beam-sensitive organic materials, particularly frozen biological samples in scanning electron microscopy (SEM).
In this webinar, our guest speaker, Dr. Ifat Kaplan will present the cryo-SEM-EDS workflow, along with imaging and spectral data that reveal the distribution of metal ions during silk processing in silkworms. SEM EDS mapping under cryo-conditions reveals the composition and spatial localization of metal ions during silk evolution within the silk gland. These findings were recently published in Nature Communications.
Join us for this informative 30-minute session to learn about the exceptional performance of the XFlash® FlatQUAD, a highly sensitive EDS detector for SEM, which is optimial for chemical mapping of biological and life science specimens. Discover how this cutting-edge technology handles even the most challenging samples with unparalleled speed (10x–50x faster than conventional EDS detectors) and sensitivity, making it a top choice for SEM EDS analysts.
Key Takeaways:
- Why the XFlash® FlatQUAD is an ideal detector for chemical mapping of life science specimens.
- Limitations of conventional large-area EDS detectors for analyzing biological materials.
- Benefits of low-kV chemical mapping with EDS in SEM.
- Fast chemical mapping of light elements (Up to Boron) in biological samples using SEM EDS.
Who Should Watch?
- Researchers, students, and industry professionals focusing on chemical analysis of biological materials.
- SEM and TEM users seeking advanced techniques for characterizing life science specimens.
- M4 TORNADO, M6 JETSTREAM, ELIO, CRONO and IRIS users.
Speakers
Dr. Purvesh Soni
Application Scientist EDS, Bruker Nano Analytics
Dr. Ifat Kaplan-Ashiri
Associate Staff Scientist, Weizmann Institute of Science
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