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PeakForce Tapping - How AFM Should Be

In PeakForce Tapping®, the probe periodically taps the sample and the pN-level interaction force is measured directly by the deflection of the cantilever. Through superior force control, the feedback loop keeps the peak force constant, down to 10 pN, in both air and fluid, which is significantly lower than is typically used with other modes, such as TappingMode™ (~1 nN).

In addition to material research, PeakForce Tapping is ideal for measurement of biological samples due to its unprecedented low imaging forces. It overcomes the many limitations of TappingMode operation in fluid, such as the need to constantly tune the cantilever. Routine measurements of live-cell mechanical properties are now available with PeakForce Tapping technology.

The superior force control maintains tip shape and sample integrity, leading to consistently accurate and high-resolution measurements of even the smallest biological structures, such as double helix DNA.

Bruker continues to demonstrate its leadership in AFM technology development with PeakForce Tapping, built on

the foundation of five separate patents. This has led to over 1,000 peer-reviewed publications in the first five years since its release, generating nearly 3000 citations. This adoption rate has surpassed even that of TappingMode.

PeakForce tapping schematic 300x300