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NMR in Pharma

The PIPAc Project - Innovation for Production on Demand in Pharma

New Methods Development for Research with NMR

New Methods Development for Research with NMR

Bruker DNP-NMR spectrometers are designed specifically for extended solid state NMR experiments, delivering unsurpassed sensitivity and stability for exciting new applications in biological solids, material science and pharmaceuticals.

New improved battery research concept

Shedding Light on the Workings of Energy Storage Materials

Energy generation and energy storage related applications require some of today’s most complex materials development initiatives to meet efficiency and reliability targets.

B.I.BioBank Tool

BioBank Metabolomics

The study of any biofluids as unique substances in each of us tiles the way for a revolution in the personalized cure, diseases prevention, allowing for early diagnosis and increasingly targeted pharmacological treatments.

Metabolomics Research in Nutrition

NMR* based Metabolomics approaches are successfully applied in food and nutrition trait optimization.

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The NMR* International COVID-19 Research Network at Work

In the current worldwide COVID-19 pandemic situation, fast developments not only in vaccines are needed, but also in analytical techniques to detect the infection, predict outcomes during hospitalization and more and more important towards Long COVID.

Covid19-NMR consortium

The Covid19-NMR Consortium

Tackling the pandemic through global collaboration

Protein

Resolution in a new dimension for solving challenges of society

The new GHz-class NMR technology is now enabling novel research in functional structural biology of proteins and protein complexes.

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NMR*- based Metabolomics Research in Cancer

Despite progress in early detection and therapeutic strategies, cancer remains a leading cause of death globally. Due to the heterogeneity and complex tumor biology, cancer patients with similar diagnoses might have different prognoses and responses to treatment.

Metabolomics Research Insights

Metabolomics Research - an Insight

Metabolomics Research at Uni Tübingen and Uni Lübeck:
We interviewed different Metabolomics research institutes to find out more about their research, daily work and latest findings.

Discover the mechanisms of antibiotics with high-field NMR

Drug Discovery Research

NMR is a powerful tool in drug discovery. NMR provides many advantages over other methods, such as the ability to directly observe chemical compounds and target biomolecules, and to be used for ligand-based and protein-based approaches

Material Science

NMR in Material Science

Giving new inisghts for a sustainable futureGreentech & New Energy concepts

Customer Insights

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Why NMR is the main detection method for food fraud and authenticity at China’s Food Fermentation Research Institute

In recent years, food fraud and food adulteration have increased significantly. The globalisation of the food chain has added new complexities to a product’s journey before it reaches the shop shelves. This has caused increased uncertainty in the food we eat, leading to consumers questioning whether what they read on the product’s label matches the ingredients inside, posing concerns around product authenticity, ingredient integrity, safety and provenance, and undeclared allergens. The reputational damage to a brand is potentially serious.

Markus Z NMR

High-field NMR and global collaboration drive Covid-19 protein research at Göttingen

As part of a 50-strong international collaboration of NMR experts, a team led by Prof. Dr. Markus Zweckstetter at the Max Planck Institute for Biophysical Chemistry in Göttingen, Germany, has been uncovering insights into the hidden workings of Covid-19. Using one of only a few 1.2 GHz NMR instruments in the world, his team is helping to elucidate the structure and interactions of the nucleocapsid protein within the SARS-CoV-2 virus and in doing so, identify promising options for drug targets.

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Israeli scientists collaborate to speed up Covid-19 RNA research using ultra-sensitive NMR techniques

As part of an international collaboration of NMR experts, a team led by Professor Lucio Frydman at the Weizmann Institute of Science, Israel, has been helping elucidate the RNA structure of Covid-19. By using sensitivity-enhancing techniques such as nuclear hyperpolarization and magnetization transfer, the team has been able to obtain insights into both the primary and secondary structures of key RNA fragments – information that should ultimately enable pharmaceutical researchers to take a step closer to discovering effective drugs.

1.2 GHz bruker Spectrometer ETH Zürich

Using AI to speed up NMR-based protein structure determination

Prof. Dr. Roland Riek, based at ETH Zürich in Switzerland, has a broad range of research interests, most of which involve the application of NMR to biological systems, and proteins in particular. But his latest project is rather different from the rest, due to its focus on how to accelerate structure determination itself, using artificial intelligence (AI) to streamline the processes of NMR data acquisition and analysis.

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Paramagnetic Resonance: A Rising Star in Battery Research Methods

An interview with Hu Bingwen, researcher at East China Normal University

Cancer research

NMR-based metabolomics: Making "precision medicine" a reality

What insights can NMR-based metabolomics provide into how cancer operates, and how therapeutic approaches might be tailored to the individual? We talk to Prof. Tone Frost Bathen about why she has valued NMR throughout her research career.

Healthy Lifestyle Diet Nutrition Concept

Personalized nutrition: The role of NMR in understanding human metabolism

Could individually tailored diets help improve health outcomes for people with diabetes, hypertension, and other chronic diseases? Prof. Elaine Holmes believes they can. With the help of nuclear magnetic resonance (NMR), she can obtain a molecule-level understanding of the differences in the way people metabolize food.

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Bringing the power of NMR to everyday healthcare

Can nuclear magnetic resonance (NMR) play a more visible role in tackling the health challenges found in today’s society? Prof. Dr. Ulrich Günther believes it can, and that prospects are looking particularly strong in the field of personalized medicine.

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The detection of air pollution through Environmentally Persistent Free Radicals (EPFRs)

In recent years, more attention has been placed on air pollution as it is increasingly becoming an invisible killer. But which type of particulate matter is most harmful to human health, and why? This is a subject that has confounded scientists and researchers for decades.

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Demystifying diseases: Using NMR to understand Covid-19 at the molecular level

With Covid-19 set to remain a global health issue for years to come, understanding the molecular machinery of the SARS-CoV-2 virus and devising new strategies to prevent it working remain high on the research agenda. As a member of the Covid-19 nuclear magnetic resonance (NMR) Consortium, Professor Dr. Teresa Carlomagno is at the forefront of this effort, and here she explains to us why the capabilities of NMR give it a special role in the biochemist’s toolkit.

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Moving metabolomics up a gear: Enhanced international collaboration enabled by NMR

To gain statistical significance from metabolomic studies of human diseases, you need a large cohort of patients willing and able to take part in medical studies – and an instrument that’s able to handle small volumes of samples and provide quantitative and reproducible analyte concentrations. Dr. Christoph Trautwein at the University of Tübingen, Germany, has been able to address both issues, thanks to the power of nuclear magnetic resonance (NMR). We talk to him about his work.

Banner CERM story Lucia Banci

High-field, high impact: How NMR collaboration at CERM, University of Florence is enhancing Covid-19 protein research

Within an international collaboration of over 50 NMR experts, a team led by Prof. Dr. Lucia Banci at CERM, University of Florence, Italy, has been helping to determine the structures of proteins found in SARS-CoV-2. Thanks to the recent installation of Bruker’s 1.2 GHz nuclear magnetic resonance (NMR) spectrometer, she has been able to provide detailed information about atomic-level interactions, and so contribute to the development of innovative approaches for drug design and optimization, for antibody validation, including those against SARS-CoV-2, and for high order structure (HOS) of biological drugs.

customer laboratory

How one of Spain’s most significant wine testing laboratories is using nuclear magnetic resonance to protect the industry

The Estación Enológica de Haro (EEH), located in the La Rioja region of Spain, is an oenological station belonging to the Government of La Rioja. Since its inception in 1892, the laboratory has become one of the country’s most significant wine testing facilities, using the latest technology to analyze Spanish wines. The EEH uses nuclear magnetic resonance (NMR) to obtain insights to quickly determine the origin and constituents in a wine sample. This in turn is helping to tackle the widespread demand for food safety and product certification. Here, Elena Melendez Alvarez and Eva Lopez Rituerto discuss their roles at the EEH and the work they carry out at the oenological station.

Osteoporosis

Solid State NMR advances understanding of osteoporosis

A team of researchers at the Centre of Bio-Medical Research (CBMR), Lucknow, India, led by Professor Dr. Sinha is using solid-state nuclear magnetic resonance (NMR) spectroscopy to dive deep into understanding bone and cartilage changes at microscopic levels with the ultimate goal of influencing patient outcomes in osterporosis.

Webinars

Understanding the structure of the SARS-CoV-2 virus through collaboration in NMR analysis holds the key to finding a treatment.

Aligning ESR technology with Sensory Panels for Beer Freshness

Understanding the structure of the SARS-CoV-2 virus through collaboration in NMR analysis holds the key to finding a treatment.

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