Analysis of Polymorphs in Solid Dosage Form using Raman Imaging
Analysis of Polymorphs in Solid Dosage Form using Raman Imaging
Fast Raman imaging is considered a promising method for evaluating polymorphs in solid dosage forms (SDFs). Furthermore, Raman imaging is a powerful tool to analyze, for example, an SDF that showed a decreased dissolution rate after stability testing. Observations revealed a crystal-to-crystal phase transition in some of the active pharmaceutical ingredient (API) particles, with the transition appearing to initiate at the particle‘s outer layer and progressively extend toward the center.
Learn more about Analysis of Polymorphs in Solid Dosage Form using Raman Imaging in our Application Note.
