Nanoscale Chemical and Structural Properties of Biological Systems from the Single Molecule to Living Organisms

Learn more about how Bruker's AFM-IR solutions support groundbreaking in-situ and single-molecule biological research.

Explore Advances in AFM-IR for Biological Materials

During this webinar, speakers discuss the ways that Bruker's photothermal infrared nanospectroscopy (AFM-IR) solutions support groundbreaking in-situ and single-molecule biological research. Their presentations include a brief introduction to Bruker's nanoIR instruments and innovative modes for nanoscale spectroscopy  as well as an in-depth exploration of:

  • Why single-molecule nanoscale imaging is important to biological research
  • How AFM-IR supports cutting-edge biological research objectives
  • How Bruker's nanoIR technology has revolutionized in in-situ and single molecule AFM-IR

Webinar Summary

During this webinar, guest speakers Dr. Francesco Simone Ruggeri (University of Cambridge) and Dr. Curtis Marcott (Light Light Solutions, Proctor & Gamble) take a closer look at the ability of cutting-edge and customized nanoIR technology to support the analysis of biological samples under physiological conditions and attain single-molecule sensitivity.

Dr. Ruggeri, a Junior Research Fellow at the Department of Chemistry of the University of Cambridge and a leader in the field of nanoIR life science applications, discusses and demonstrates his research using infrared absorption nanospectroscopy to unravel the chemical and biophysical state of the biomolecules of life.

In his portion of the presentation, Dr. Ruggeri considers and discusses:

  1. The limitations of traditional single-property mapping techniques for developing a complete understanding of the inner biophysical properties of heterogeneous biological samples — and how AFM-IR navigates or circumvents these challenges.
  2. How his research leverages thermomechanical detection and AFM-IR to enhance the chemical and structural sensitivity of nanoIR instruments.
  3. How his research demonstrates nanoscale chemical sensitivity in physiological environments.


This webinar was presented on: August 19, 2020

Find out more information about Bruker's solutions for AFM-IR Spectroscopy:


Dr. Francesco Simone Ruggeri, Wageningen University

Dr. Francesco Simone Ruggeri joined the chair groups of Organic Chemistry and Physical Chemistry of Wageningen University as Assistant Professor in 2020. Before this, he completed his independent Junior Research Fellowship at the Darwin College and post-doctoral research at the Department of Chemistry & Centre for Misfolding disease at the University of Cambridge, UK. He holds a Ph.D. in biophysics obtained in 2015 at the École Polytechnique Fédérale de Lausanne (EPFL) in Switzerland, where he acquired a strong expertise in scanning probe microscopy and single molecule methods.

Dr. Curtis Marcott

Senior Partner, Light Light Solutions; Previous: Technical fellow at Proctor & Gamble