Nanoscale Chemical and Structural Properties of Biological Systems from the Single Molecule to Living Organisms

with guest Dr. Ruggeri, University of Cambridge

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Explore Advances in AFM-IR for Biological Materials

In this webinar, Nanoscale Chemical and Structural Properties of Biological Systems from the Single Molecule to Living Organisms, our speakers discuss the ways that AFM-IR — and, specifically, Bruker's AFM-IR solutions — support groundbreaking in-situ and single molecule biological research.

Their presentations include a brief introduction to Bruker's nanoIR instruments and our innovative modes for nanoscale spectrosopy, as well as an in-depth exploration of:

  1. Why single molecule nanoscale imaging is important to biological research;
  2. How infrared nanospectroscopy (AFM-IR) supports cutting-edge biological research objectives; and
  3. How Bruker's nanoIR technology has contributed to recent breakthroughs in in-situ and single molecule AFM-IR.


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Key Topics

During this webinar, both of our guest speakers — Dr. Francesco Simone Ruggeri (University of Cambridge) and Dr. Curtis Marcott (Light Light Solutions, Proctor & Gamble) — take a closer look at the ability of cutting-edge and customized nanoIR technology to support the analysis of biological samples under physiological conditions and attain single-molecule sensitivity.

Moreover, Dr. Ruggeri, a Junior Research Fellow at the Department of Chemistry of the University of Cambridge and a leader in the field of nanoIR life science applications, discusses and demonstrates his research using infrared absorption nanospectroscopy to unravel the chemical and biophysical state of the biomolecules of life.

In his portion of the presentation, Dr. Ruggeri pays particular attention to:

  1. The limitations of traditional single property mapping techniques for developing a complete understanding of the inner biophysical properties of heterogeneous biological samples — and how AFM-IR navigates these challenges.
  2. How his research leverages thermomechanical detection and AFM-IR to enhance the chemical and structural sensitivity of nanoIR instruments.
  3. How his research demonstrates nanoscale chemical sensitivity in physiological environments.

Dr. Ruggeri also goes on to answer questions submitted by the audience.


This webinar was presented on: August 19, 2020


Dr. Curtis Marcott

Senior Partner, Light Light Solutions; Previous: Technical fellow at Proctor & Gamble

Dr. Francesco Simone Ruggeri, Wageningen University

Dr. Francesco Simone Ruggeri joined the chair groups of Organic Chemistry and Physical Chemistry of Wageningen University as Assistant Professor in 2020. Before this, he completed his independent Junior Research Fellowship at the Darwin College and post-doctoral research at the Department of Chemistry & Centre for Misfolding disease at the University of Cambridge, UK. He holds a Ph.D. in biophysics obtained in 2015 at the École Polytechnique Fédérale de Lausanne (EPFL) in Switzerland, where he acquired a strong expertise in scanning probe microscopy and single molecule methods.