In this webinar, Dr. Myriam Chaumeil from the University of California, San Francisco, will discuss emerging applications for HP-13C MRI in detection of inflammatory cells, such as macrophages, involved in neuroinflammation in various preclinical models, and the potential for this method to fill current gaps in clinical imaging techniques currently available.
The metabolic reprogramming that occurs when inflammatory cells are activated as part of the immune response can be targeted by HP-13C probes in a manner similar to techniques imaging metabolically active cancer cells. This resemblance prompted Chaumeil and colleagues to evaluate the technique for the detection and monitoring of neuroinflammation in cells (e.g. macrophages) and various diseases models, including multiple sclerosis, traumatic brain injury, and Alzheimer’s disease.
Data on models of neurological conditions will be presented, as well as a review of what other researchers in the field have been doing. Bruker’s Preclinical BioSpec 3T operating with a cryogen-free magnet, will be introduced, as will plans to develop new probes and translate the methodology to the clinic in the future.
This webinar would appeal to pre-clinical researchers, people interested in imaging neurological disorders and neuroscientists who are working in industry or academia. It would also appeal to clinicians interested in potential future applications and scientists involved in novel MRI applications.
Dr. Myriam Chaumeil
Assistant Professor in residence Department of Physical Therapy and Rehabilitation Science Department of Radiology and Biomedical Imaging University of California, San Francisco (UCSF)
Todd Sasser, PhD
Head of Applications PCI, Americas Bruker BioSpin Billerica, Massachusetts