Chemical exchange saturation transfer (CEST) is a technique that may be applied to a number of disease areas. In oncology applications, for example, amide CEST can distinguish radiation necrosis from tumor progression as well as early response to chemotherapy. However, such therapies often affect the tissue pH and the local T1 and T2 relaxation times for the bulk water and so it is challenging to quantify the resulting exchange contrast. In this webinar, radiologist Christian Farrar (Harvard Medical School) will discuss how a recently developed rapid, quantitative and efficient MRI fingerprinting method could make CEST MRI a more quantitative technique.
Dr. Farrar will report on initial applications of this new fingerprinting CEST MRI method. Using stroke and cancer models as examples, he will describe how the technique enables quantitative assessment of changes in underlying tissue parameters through the generation of quantitative exchange rate and exchangeable proton concentration maps.
The main topics that will be covered include:
With applications spanning almost any disease area, from cancer, stroke, neurodegenerative disease, through to cardiac metabolism disorders, this new MR fingerprinting method would interest anyone involved in pathology from an academic, industry or pharmaceutical R&D perspective, as well as those involved in the physics of MRI.
Dr. Christian Farrar
Assistant professor in the Department of Radiology at Harvard Medical School