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固体形式量化——一种新的小型解决方案

Quantification of components in solid mixtures like formulated materials is crucial in material sciences. Especially in the pharmaceutical industry, API (Active Pharmaceutical Ingredient) form quantification plays a central role from early drug development to manufacturing. The new benchtop solution the minispec Form Check offers an easy and non-destructive way to determine the ratio of either different drug components or various solid forms in a substance.
This webinar took place on May 08th 2018

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概述

布鲁克推出了一种简单易用的方法,通过将可靠的minispec mq20小型系统与成熟的Dynamics Center软件结合到小核磁分析仪形态检查中,快速量化固体形态,包括非晶化。网络研讨会将着重讨论作为待审专利的固体形态量化方法与目前使用的方法相对比的优势,如固态核磁共振、X射线粉末衍射或热重法。

网络研讨会将展示它的易用性,以及任何可能没有接受过核磁共振训练的人如何使用这种新方法。因此,快速、直接的校准和自动化数据分析将成为研究的重点。最后对可能的应用领域进行概述。

期望

在对TD-NMR(时域核磁共振)进行简短概述之后,网络研讨会将集中于小核磁分析仪形态检查方法的易用性(非核磁共振专家也参会)以及与现有方法相比的优势。本文将详细介绍如何区分两种不同的固体形态,检测lead API的浓度,并概述这种固体形态量化方法的潜力。

 

 

重点话题

TD NMR综述

·        什么是时域核磁共振

·        易用性:非专家工作流程

·        小核磁分析仪mq20:成本低,占地面积小,无冷冻剂,多功能

 

 

固态形式量化

  • 固体形态量化:

    ·        非破坏性和非侵扰性

    ·        样本纹理:粉末、片剂、凝胶

    ·        快速直接校准

    ·        通过1H或19F信息确定质量百分比的比率

    ·        表征API固体形态:包括非晶化以及与赋形剂的相互作用

参与人员

网络研讨会针对制药行业的人员,特别是那些参与药物开发的人员,也涉及药品生产的人员。网络研讨会也引起了其他行业人员的兴趣,这些人员在制备固体混合物方面面临各种问题与挑战。

Speakers

Dr. Venita Decker
Dr. Venita Decker
Product Manager FT-NMR benchtop solutions, BBIO, Bruker BioSpin, Rheinstetten, Germany
Dr. Venita Decker studied Neuroscience, but did her dissertation in the field of solid-state NMR (Max Planck Institute for Biophysical Chemistry, Goettingen). In 2012, she joined the Bruker solid-state NMR application. As a NMR-late entrant she since then actively supported Bruker solutions that simplify the complexity of NMR (TopSolids, the minispec FormCheck). Since 2018, she is the Product Manager for FT-NMR benchtop solutions, bringing her mission to the next level.
Dr. Marcio Cobo
Dr. Marcio Cobo
Application Manager / Developer for TD-NMR in the Applied, Industrial and Clinical (AIC) division
Studied Physics at the University of Sao Paulo and did his dissertation in the field of solid-state and Time Domain NMR at the Institute of Physics of Sao Carlos.