Studying Cardiovascular Pathology with MRI

用MRI研究心血管病理学

Cardiovascular disease due to atherosclerosis is the leading cause of disease and mortality worldwide. So-called “vulnerable” atherosclerotic plaques are those that are likely to result in clinical events. One of the hallmarks of vulnerable plaques is increased endothelial permeability, a feature that is related to the progression of the disease across all stages of the atherosclerotic cascade.
This webinar took place on September 20th 2018

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概述

在动脉粥样硬化开始时增加的内皮通透性导致脂质沉积和斑块形成。在后期阶段它与斑块炎症和炎症细胞的外渗相关,这些炎症细胞在斑块发展时产生,并且可能最终导致斑块破裂。此次网络研讨会将描述核磁共振成像(MRI)用于监测小鼠动脉粥样硬化斑块内皮通透性增加,使用临床前Bruker Biospec 7 Tesla水平70/30扫描仪和自门控功能(IntraGate)。自门控成像可实现高质量的心脏MRI,无额外硬件要求(如使用ECG电极)但存在信号干扰和破坏的潜在缺陷,已在我们的实验室中用于获得小鼠主动脉根的清晰成像。

 

 

预期

本文将讨论基本的自门控成像,以及在心脏和血管MRI中应用这种方法的优点。  这种灵活的工具可以实现高质量、高分辨率的临床前心脏和血管成像,而不需要ECG触发,这意味着无需电极和门控装置。

 

 

主要议题

  • 用MRI研究小鼠主动脉根部的动脉粥样硬化,而重点是内皮通透性
  • 使用布鲁克BioSpec 70/30 USR和自门控成像(IntraGate软件包)进行主动脉根和升主动脉的2D动态对比度增强(DCE)MRI和3D T1映射
  • 使用自门控技术进行心脏和血管成像的优势
  • 这些技术为从事临床前成像工作的工作人员提供了灵活性

谁应参会?

此次网络研讨会对有兴趣研究小动物的心脏和血管成像的群体有用,特别是使用MRI。对于在临床扫描仪上成像较大动物但对小动物成像也感兴趣的研究人员来说,这也是有用的,可以进行更深入的机械研究。对心血管疾病病理学感兴趣的人员也会被网络研讨会所吸引。

 

 

Speakers

Claudia Calcagno Mani, MD, PhD
Claudia Calcagno Mani, MD, PhD
Assistant Professor Department of Radiology Translational and Molecular Imaging Institute Icahn School of Medicine at Mount Sinai New York, USA
Dr. Claudia Calcagno holds an MD from the University of Genova (Italy, 2004), and a PhD from the Icahn School of Medicine at Mount Sinai/ New York University (New York, USA, 2010). He main research interest is dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) of the atherosclerotic arterial vessel wall.
Todd Sasser, PhD
Todd Sasser, PhD
Head of Applications PCI, Americas Bruker BioSpin Billerica, Massachusetts
Todd Sasser is a Field Applications Scientist for Bruker Preclinical Imaging. He provides application support for in vivo imaging across a wide variety of disciplines from infection imaging, cancer biology, and probe development. He currently focuses on application development for the Albira PET/SPECT/CT system. Dr. Sasser studied at The University of Liverpool and The University of Hawaii and is currently a visiting scholar at The University of Notre Dame.