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microCT Applications in Lung Research and Immunology

The ability to quantitate lung disease and monitor disease development and resolution in real time is an advantage to using small animal microCT. In addition, 3D analysis provides data about the whole lung instead of the snap-shots typically associated with conventional analysis techniques, including histology. microCT provides the ability to assess a large diversity of lung diseases and the outcomes correlated to data generated from human patients.

In this webinar, Dr. Elizabeth Redente, Associate Professor at National Jewish Health, will give insights from the literature and her group on the ability of microCT imaging to quantitate, visualize and follow the development of a myriad of lung diseases including inflammation associated with infection, fibrosis, emphysema and tumor development. The use of 3-dimensional analysis to quantify lung disease is advantageous over traditional histology techniques that capture a single cross-sectional analysis or macro-dissection of the lung to isolate tumors, which reduces spatial understanding. In addition, the use of contrast agents allows for easy visualization and quantitation of organ vasculature.

This webinar took place on May 28th, 2020  

Who to Expect

In this webinar, Dr. Redente will discuss the advantages of microCT and provide a broad overview of the many pulmonary diseases that this imaging modality can visualize. This is a highly innovate technique and can be used to analysing living animals as well as fixed tissue. Examples from the literature will be provided as well as work from Dr. Redente’s laboratory.

Key Topics


microCT of lung

  • Current methods and limitations
  • Use of contrast agents



Examples of lung diseases

  • Fibrosis
  • Infections disease and inflammation
  • Emphysema
  • Lung cancer

Quantitation and visualization

  • Lung volumes
  • Hounsfield Units
  • Emphysema
  • Tumor counting



Benefits

  • Higher differentiation of lung tissue and airspace
  • High resolution images
  • Low radiation dosage for longitudinal scans
  • 3D reconstruction and visualization

Who Should Attend?

Researchers (undergraduates, graduates, postdoctoral fellows) in biomedical sciences who are interested in a gaining a better understanding of µCT techniques as well as an overview of current µCT research.

Speakers

Dr. Elizabeth Redente

Associate Professor National Jewish Health