Label-free techniques for Drug Discovery:
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Surface Plasmon Resonance (SPR) and MALDI Mass Spectrometry for Primary (HTS) and Secondary Screening
The webinar will update on latest developments in MALDI mass spectrometry for high-throughput screening and CPD profiling (rapifleX MALDI PharmaPulse) and introduce Bruker's new surface plasmon resonance (SPR) instrument, the SIERRA SPR-32. Beside technical details explaining the latest developments, synergies between MALDI mass spectrometry and SPR will be discussed.
- Primary and Secondary Screening in Drug Discovery
- Label-free technologies to reduce artefacts / importance of controls in SPR experiments
- Kinetic characterization: Determination of KDon- and KDoff-rates of compounds (SPR)
- Automation strategies to maximize throughput (SPR and MALDI)