Clinical Methods and Applications of Hyperpolarized 129Xe MRI for Functional Imaging of the Lungs and Other Organs

2015 marked the first ever translation of hyperpolarized gas MRI to diagnostic clinical practice. Research at the University of Sheffield now continues with hyperpolarized 3He and 129Xe gas lung MRI and asthma, COPD, cystic fibrosis, interstitial lung disease, lung cancer and pulmonary hypertension.

In this webinar, Prof. Jim Wild, head of POLARIS (Pulmonary, Lung and Respiratory Imaging Sheffield) at the University of Sheffield will cover all aspects of methodology for hyperpolarized 129Xe MRI in humans including, polarizer physics, RF coils, pulse sequence design, and functional imaging methods to study microstructure, gas exchange, air flow. It will also shed light on regulatory aspects as well as giving an overview of clinical applications in the lungs and other organs.

This webinar took place on July 23rd, 2020  

What to Expect

In this webinar, Wild will share his extensive knowledge on hyperpolarization lung imaging in humans and share insight into the novel pulmonary therapies using hyperpolarized gas and proton lung MRI as markers that his group is evaluating in collaboration with pharmaceutical companies.

Key Topics

Pulmonary Imaging

  • Translation of hyperpolarized gas MRI to diagnostic clinical practice
  • Novel pulmonary therapies
  • Measuring and modelling lung physiology and microstructure

Hyperpolarization Imaging

  • RF coil engineering for 3He and 129Xe MRI
  • Rapid acquisition methods - radial, compressed sensing, steady state free precession and parallel imaging
  • Techniques for simultaneous imaging of 1H, 3He and 129Xe in the lungs

Who Should Attend

Researchers focusing on pulmonary treatments will find this webinar particularly beneficial. This webinar is additionally valuable to MRI scientists interested in hyperpolarization and all researchers desiring to gain more insight into the process of translation of fundamental research to the clinic.


Professor. Jim Wild

POLARIS (Pulmonary, Lung and Respiratory Imaging Sheffield) University of Sheffield

Jim Wild is a professor at the University of Sheffield and head of POLARIS (Pulmonary, Lung and Respiratory Imaging Sheffield). He is renowned for being the first to internationally translate hyperpolarized gas MRI to diagnostic clinical practice.

Dr. Kumar Changani

Sales Manager for the UK, Ireland and the Nordic regions for Bruker

Kumar graduated at London University in Biochemistry and completed his PhD into gestational diabetes at Imperial College and QMUL using imaging and spectroscopy techniques. Following several post-doctoral positions he directed the UK preclinical imaging activities at GlaxoSmithKline as well as leading various lead-optimisation respiratory biology programmes. In 2018 he took up the role of Preclinical Sales Manager (UK, IRE, Nordic) for Bruker. Kumar has published over 50 papers as well as book chapters.