In this webinar, Dr. Mathieu D. Santin from ICM, Paris, France, will describe methods and results obtained for in and ex vivo imaging at ultra-high field in the context of neurodegenerative diseases (demyelinating diseases, Alzheimer disease, multiple sclerosis…). For the investigation of such diseases at UHF Santin primarily implements Multi Gradient Echo (MGE) and 3D-segmented Diffusion EPI techniques. Other innovative studies combining ultrasound and MRI to open the blood brain barrier will be discussed as well. Focused Ultrasound (FUS) are used for instance for cortical activations in primates (Transcranial Focused Ultrasound) but also for non-invasively modulating the visual cortex activity of primates by local ultrasound-induced delivery of an inhibitory neurotransmitter (GABA) : transient disruption of the blood brain barrier (BBB) with FUS coupled with ultrasound contrast agents (UCA).
MR methods for high resolution imaging, diffusion weighted imaging, quantitative susceptibility mapping applied to neurodegenerative diseases; use of Focused-ultrasound combined with MRI studies (cortical activations, blood brain barrier opening…).
People interested in preclinical MRI, ex vivo MRI, neurodegenerative diseases, highly-resolved anatomical and diffusion MRI, Quantitative Susceptibility Mapping, ultrasound-based MRI studies.
Dr. Mathieu D. Santin
Project leader, Neuroimaging platform, CENIR, Brain and Spine Institute (ICM), Paris, France.