MALDI-MS is a fast, label-free technology for assays in pharmaceutical R&D and chemical biology. Recently, CeMOS has pioneered MALDI-MS based cell assays for drug profiling and screening, in part in a collaboration with a pharma company. The first part of the webinar will present examples of MALDI-MS phenotypic and mechanistic cell assays. It will cover the discovery of potential cellular drug response markers, characterization of potent fatty acid synthase inhibitors. The second part will introduce the use of MALDI-MS instead of radioisotope- or fluorescence-based methods for investigation of cellular drug uptake, assay automation and evaluation of drug-drug interactions mediated by the transporter OATP2B1. Characterization of this transporter, screening of 300 drugs for inhibition of uptake and IC50 calculation for hit compounds will be presented.
Prof. Dr. Carsten Hopf
Professor and Head of CeMOS
Melissa Unger, M.Sc
Scientist at CeMOS
For Research Use Only. Not for use in clinical diagnostic procedures.